CHRM3 rs2165870 polymorphism is independently associated with postoperative nausea and vomiting, but combined prophylaxis is effective

• Published in: British journal of anaesthesia : BJA Vol. 121; no. 1; pp. 58 - 65
• Main Authors: Klenke, S., de Vries, G.J., Schiefer, L., Seyffert, N., Bachmann, H.S., Peters, J., Frey, U.H.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2018
• Subjects: genetic predisposition; pharmacogenetics; PONV; rs2165870; genetic predisposition; PONV; rs2165870; pharmacogenetics

Clinical risk factors for postoperative nausea and vomiting (PONV) are evaluated with the Apfel score, however patients with low Apfel scores still experience PONV suggesting a genetic predisposition. PONV risk associates with specific M3 muscarinic acetylcholine receptor (CHRM3) rs 2165870 polymorp...