The N-butyl alcohol extract from Hibiscus rosa-sinensis L. flowers enhances healing potential on rat excisional wounds
Hibiscus rosa-sinensis L. (HRS), a folk medicine named Zhujin in China, possess anti-tumor, antioxidant, antibacterial, low density lipoprotein oxidation prevention and macrophage death prevention effects. The leaves and red flowers of HRS have been traditionally used to treat with furuncle and ulce...
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Published in | Journal of ethnopharmacology Vol. 198; pp. 291 - 301 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
23.02.2017
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Abstract | Hibiscus rosa-sinensis L. (HRS), a folk medicine named Zhujin in China, possess anti-tumor, antioxidant, antibacterial, low density lipoprotein oxidation prevention and macrophage death prevention effects. The leaves and red flowers of HRS have been traditionally used to treat with furuncle and ulceration.
To investigate the efficacy and possible mechanism of the N-butyl alcohol extract of HRS (NHRS) red flowers in wound healing by analyzing the collagen fiber deposition, angiogenic activity and macrophages action of the NHRS.
In an excisional wound healing model in rats, different concentrations of NHRS, or recombinant bovine basic fibroblast growth factor (rbFGF), were respectively applied twice daily for 9 days. Histopathology was assessed on day 9 via hematoxylin and eosin (HE) and Masson's trichrome (MT) staining, and immunohistochemistry for vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1) and CD68. Immunomodulation by NHRS was evaluated by a carbon clearance test in mice.
Wound healing post-surgery was greater in the rbFGF-control, NHRS-M and MHRS-H groups than in the model and 5% dimethylsulfoxide (DMSO)-control groups after the third day. By the sixth day the wound contraction of NHRS-M and MHRS-H groups was much higher than the rbFGF-control group. HE and MT staining revealed that epithelialization, fibroblast distribution, collagen deposition of NHRS-M- and NHRS-H-control groups were significantly higher than the model group. Moreover, immunohistochemistry showed more intense staining of VEGF, TGF-β1 and CD68 in the rbFGF- and NHRS-control groups, compared to that in model and 5% DMSO-control groups. The clearance and phagocytic indices of NHRS-M- and NHRS-H-control groups were significantly higher than that of the carboxyl methyl cellulose (CMC) group in mice.
NHRS accelerates wound repair via enhancing the macrophages activity, accelerating angiogenesis and collagen fiber deposition response mediated by VEGF and TGF-β1.
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AbstractList | Hibiscus rosa-sinensis L. (HRS), a folk medicine named Zhujin in China, possess anti-tumor, antioxidant, antibacterial, low density lipoprotein oxidation prevention and macrophage death prevention effects. The leaves and red flowers of HRS have been traditionally used to treat with furuncle and ulceration.
To investigate the efficacy and possible mechanism of the N-butyl alcohol extract of HRS (NHRS) red flowers in wound healing by analyzing the collagen fiber deposition, angiogenic activity and macrophages action of the NHRS.
In an excisional wound healing model in rats, different concentrations of NHRS, or recombinant bovine basic fibroblast growth factor (rbFGF), were respectively applied twice daily for 9 days. Histopathology was assessed on day 9 via hematoxylin and eosin (HE) and Masson's trichrome (MT) staining, and immunohistochemistry for vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1) and CD68. Immunomodulation by NHRS was evaluated by a carbon clearance test in mice.
Wound healing post-surgery was greater in the rbFGF-control, NHRS-M and MHRS-H groups than in the model and 5% dimethylsulfoxide (DMSO)-control groups after the third day. By the sixth day the wound contraction of NHRS-M and MHRS-H groups was much higher than the rbFGF-control group. HE and MT staining revealed that epithelialization, fibroblast distribution, collagen deposition of NHRS-M- and NHRS-H-control groups were significantly higher than the model group. Moreover, immunohistochemistry showed more intense staining of VEGF, TGF-β1 and CD68 in the rbFGF- and NHRS-control groups, compared to that in model and 5% DMSO-control groups. The clearance and phagocytic indices of NHRS-M- and NHRS-H-control groups were significantly higher than that of the carboxyl methyl cellulose (CMC) group in mice.
NHRS accelerates wound repair via enhancing the macrophages activity, accelerating angiogenesis and collagen fiber deposition response mediated by VEGF and TGF-β1. Hibiscus rosa-sinensis L. (HRS), a folk medicine named Zhujin in China, possess anti-tumor, antioxidant, antibacterial, low density lipoprotein oxidation prevention and macrophage death prevention effects. The leaves and red flowers of HRS have been traditionally used to treat with furuncle and ulceration. To investigate the efficacy and possible mechanism of the N-butyl alcohol extract of HRS (NHRS) red flowers in wound healing by analyzing the collagen fiber deposition, angiogenic activity and macrophages action of the NHRS. In an excisional wound healing model in rats, different concentrations of NHRS, or recombinant bovine basic fibroblast growth factor (rbFGF), were respectively applied twice daily for 9 days. Histopathology was assessed on day 9 via hematoxylin and eosin (HE) and Masson's trichrome (MT) staining, and immunohistochemistry for vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1) and CD68. Immunomodulation by NHRS was evaluated by a carbon clearance test in mice. Wound healing post-surgery was greater in the rbFGF-control, NHRS-M and MHRS-H groups than in the model and 5% dimethylsulfoxide (DMSO)-control groups after the third day. By the sixth day the wound contraction of NHRS-M and MHRS-H groups was much higher than the rbFGF-control group. HE and MT staining revealed that epithelialization, fibroblast distribution, collagen deposition of NHRS-M- and NHRS-H-control groups were significantly higher than the model group. Moreover, immunohistochemistry showed more intense staining of VEGF, TGF-β1 and CD68 in the rbFGF- and NHRS-control groups, compared to that in model and 5% DMSO-control groups. The clearance and phagocytic indices of NHRS-M- and NHRS-H-control groups were significantly higher than that of the carboxyl methyl cellulose (CMC) group in mice. NHRS accelerates wound repair via enhancing the macrophages activity, accelerating angiogenesis and collagen fiber deposition response mediated by VEGF and TGF-β1. [Display omitted] |
Author | Wang, Yuan-Hang Shi, Gang-Gang Jiang, Ji-Yang Shen, Hui-Min Chen, Chun Cai, Wen-Feng Ling, Zhen Zheng, Yi-Lin Tang, Liu Wang, Bin |
Author_xml | – sequence: 1 givenname: Hui-Min surname: Shen fullname: Shen, Hui-Min – sequence: 2 givenname: Chun surname: Chen fullname: Chen, Chun – sequence: 3 givenname: Ji-Yang surname: Jiang fullname: Jiang, Ji-Yang – sequence: 4 givenname: Yi-Lin surname: Zheng fullname: Zheng, Yi-Lin – sequence: 5 givenname: Wen-Feng surname: Cai fullname: Cai, Wen-Feng – sequence: 6 givenname: Bin surname: Wang fullname: Wang, Bin – sequence: 7 givenname: Zhen surname: Ling fullname: Ling, Zhen – sequence: 8 givenname: Liu surname: Tang fullname: Tang, Liu – sequence: 9 givenname: Yuan-Hang surname: Wang fullname: Wang, Yuan-Hang – sequence: 10 givenname: Gang-Gang surname: Shi fullname: Shi, Gang-Gang email: ggshi@stu.edu.cn |
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CitedBy_id | crossref_primary_10_1016_j_ijpharm_2022_121617 crossref_primary_10_1016_j_ygeno_2019_04_010 crossref_primary_10_2174_1567201818666210727165916 crossref_primary_10_3390_antibiotics10111343 crossref_primary_10_1039_C8BM01196F crossref_primary_10_3390_app122211777 crossref_primary_10_1088_1748_605X_acce89 crossref_primary_10_1111_jphp_12977 crossref_primary_10_1016_j_jff_2020_104291 crossref_primary_10_1016_j_sjbs_2019_11_002 crossref_primary_10_1016_j_biopha_2021_111225 crossref_primary_10_1016_j_phymed_2023_155000 crossref_primary_10_1016_j_jss_2019_09_011 crossref_primary_10_1155_2017_8407249 crossref_primary_10_1155_2019_2684108 crossref_primary_10_2174_012210299X257271231124075042 crossref_primary_10_1016_j_jep_2020_113408 crossref_primary_10_1016_j_sjbs_2020_07_008 crossref_primary_10_1177_1534734620921629 crossref_primary_10_1002_mabi_201800041 |
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Keywords | rbFGF C Hibiscus rosa-sinensis L D DMSO E HRS SD BV CMC IC Vascular endothelial growth factor NHRS SUMC CD Wound healing VEGF AG MT CP GT ECM Transforming growth factor-β1 TGF-β1 VP HE Macrophage |
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SubjectTerms | 1-Butanol - chemistry Animals Antigens, CD - metabolism Antigens, Differentiation, Myelomonocytic - metabolism Cattle Collagen - metabolism Disease Models, Animal Dose-Response Relationship, Drug Female Fibroblast Growth Factor 2 - administration & dosage Fibroblast Growth Factor 2 - pharmacology Flowers Hibiscus - chemistry Hibiscus rosa-sinensis L Macrophage Male Mice Neovascularization, Physiologic - drug effects Plant Extracts - administration & dosage Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Transforming Growth Factor beta1 - metabolism Transforming growth factor-β1 Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Wound healing Wound Healing - drug effects |
Title | The N-butyl alcohol extract from Hibiscus rosa-sinensis L. flowers enhances healing potential on rat excisional wounds |
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