Nanoparticle formulations: A smart era of advanced treatment with nanotoxicological imprints on the human body

• Published in: Chemico-biological interactions Vol. 373; p. 110355
• Main Authors: Singh, Siddharth, Jaiswal, Vishakha, Singh, Jangjeet Karan, Semwal, Ravindra, Raina, Deepika
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.03.2023
• Subjects: Central Nervous System (CNS); Interaction; Nanoparticles; Neuronal cell; Toxicity; Nanoparticles; Toxicity; Central Nervous System (CNS); Interaction; Neuronal cell
• ISSN: 0009-2797; 1872-7786
• DOI: 10.1016/j.cbi.2023.110355

In the modern era, nanoparticles are the preferred dosage form, and maximum research is going on in the field of nanoparticle formulations. But as they are so small, nanoparticles are able to slip through the body's defenses and cause damage to the organs and tissues deep inside. In recent years, most researchers have focused solely on the therapeutic value of drugs or, at times, the performance of dosage forms, but few have given toxicity studies equal weight in their research. This review demonstrates that nanoparticle formulations are not suitable from a safety standpoint. So, researchers should be focused on alternative formulations like nanoemulsion, nanogel, and other liquids as well as semisolid formulations. •Nanoparticles produce ROS species that lead to oxidative stress.•Metal-based nanoparticles damage the genetic material of the cells.•Nanoparticles alter cell shape and mitochondrial functions.•Nanoparticles cause platelet aggregation and alter the immune system's reaction toward common allergens.