A Modeling Conundrum: Murine Models for Cutaneous Wound Healing
The complexity of the cutaneous wound healing process and its impairment in disease states, combined with the urgent clinical need for new therapies demand well-defined preclinical models that facilitate translation of research findings to clinical use. Many murine wound models are well suited for s...
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| Published in | Journal of investigative dermatology Vol. 138; no. 4; pp. 736 - 740 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.04.2018
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| Online Access | Get full text |
| ISSN | 0022-202X 1523-1747 1523-1747 |
| DOI | 10.1016/j.jid.2017.12.001 |
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| Abstract | The complexity of the cutaneous wound healing process and its impairment in disease states, combined with the urgent clinical need for new therapies demand well-defined preclinical models that facilitate translation of research findings to clinical use. Many murine wound models are well suited for studying mechanisms of various aspects of wound healing, but they have shown limited utility for translating research findings to human conditions, thereby impeding therapeutic developments. Ansell et al. underscore the need for standardization of preclinical murine models by showing the impact of duration of diabetes, animal sex, and assessment methods on healing outcomes in the streptozotocin-induced diabetes mellitus rat model. Recognizing and understanding the limitations and advantages of preclinical murine wound models will facilitate more effective translation of experimental results to improved treatment of human chronic wounds. |
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| AbstractList | The complexity of the cutaneous wound healing process and its impairment in disease states, combined with the urgent clinical need for new therapies demand well-defined preclinical models that facilitate translation of research findings to clinical use. Many murine wound models are well suited for studying mechanisms of various aspects of wound healing, but they have shown limited utility for translating research findings to human conditions, thereby impeding therapeutic developments. Ansell et al. underscore the need for standardization of preclinical murine models by showing the impact of duration of diabetes, animal sex, and assessment methods on healing outcomes in the streptozotocin-induced diabetes mellitus rat model. Recognizing and understanding the limitations and advantages of preclinical murine wound models will facilitate more effective translation of experimental results to improved treatment of human chronic wounds. The complexity of the cutaneous wound healing process and its impairment in disease states, combined with the urgent clinical need for new therapies demand well-defined preclinical models that facilitate translation of research findings to clinical use. Many murine wound models are well suited for studying mechanisms of various aspects of wound healing, but they have shown limited utility for translating research findings to human conditions, thereby impeding therapeutic developments. Ansell et al. underscore the need for standardization of preclinical murine models by showing the impact of duration of diabetes, animal sex, and assessment methods on healing outcomes in the streptozotocin-induced diabetes mellitus rat model. Recognizing and understanding the limitations and advantages of preclinical murine wound models will facilitate more effective translation of experimental results to improved treatment of human chronic wounds.The complexity of the cutaneous wound healing process and its impairment in disease states, combined with the urgent clinical need for new therapies demand well-defined preclinical models that facilitate translation of research findings to clinical use. Many murine wound models are well suited for studying mechanisms of various aspects of wound healing, but they have shown limited utility for translating research findings to human conditions, thereby impeding therapeutic developments. Ansell et al. underscore the need for standardization of preclinical murine models by showing the impact of duration of diabetes, animal sex, and assessment methods on healing outcomes in the streptozotocin-induced diabetes mellitus rat model. Recognizing and understanding the limitations and advantages of preclinical murine wound models will facilitate more effective translation of experimental results to improved treatment of human chronic wounds. |
| Author | Wikramanayake, Tongyu C. Tomic-Canic, Marjana Jozic, Ivan Elliot, Sharon |
| Author_xml | – sequence: 1 givenname: Sharon surname: Elliot fullname: Elliot, Sharon organization: DeWitt Daughtry Family Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida, USA – sequence: 2 givenname: Tongyu C. surname: Wikramanayake fullname: Wikramanayake, Tongyu C. organization: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller Medical School, Miami, Florida, USA – sequence: 3 givenname: Ivan surname: Jozic fullname: Jozic, Ivan organization: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller Medical School, Miami, Florida, USA – sequence: 4 givenname: Marjana surname: Tomic-Canic fullname: Tomic-Canic, Marjana email: mtcanic@med.miami.edu organization: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller Medical School, Miami, Florida, USA |
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| Cites_doi | 10.1016/j.lfs.2016.03.019 10.4161/derm.23872 10.1016/S0140-6736(05)64954-9 10.1111/wrr.12109 10.1080/13685530500233847 10.1111/j.1524-475X.2011.00757.x 10.1007/s12020-013-0144-3 10.1126/scitranslmed.3009337 10.1016/S0002-9440(10)65217-0 10.1111/wrr.12245 10.1038/jid.2010.334 10.1186/gb-2008-9-5-r80 10.1016/j.exger.2006.11.018 10.1016/j.jid.2017.10.020 10.1097/01.BCR.0000202898.11277.58 10.2353/ajpath.2010.090432 10.1016/j.jid.2016.08.009 |
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