A microfluidic platform with integrated flow sensing for focal chemical stimulation of cells and tissue

A microfluidic platform for precise biochemical control of the extracellular microenvironment was developed. A chemical interface was established with cells or tissues through the precise and focal delivery of soluble chemical agents through a pore addressed by a polymer microchannel. Thermal flow s...

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Bibliographic Details
Published inSensors and actuators. B, Chemical Vol. 152; no. 2; pp. 267 - 276
Main Authors Kuo, Jonathan T.W., Chang, Li-Yuan, Li, Po-Ying, Hoang, Tuan, Meng, Ellis
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2011
Subjects
Actuators
Biochemistry
cells
Chemical interface
Fluid delivery
Fluid dynamics
Focal chemical stimulation
Microchannels
Microfluidics
Neural interface
Parylene C
Platforms
polymers
Porosity
Sensors
sensors (equipment)
Stimulation
Chemical interface
Focal chemical stimulation
Parylene C
Fluid delivery
Neural interface
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Summary:A microfluidic platform for precise biochemical control of the extracellular microenvironment was developed. A chemical interface was established with cells or tissues through the precise and focal delivery of soluble chemical agents through a pore addressed by a polymer microchannel. Thermal flow sensors were integrated along the length of the microchannel and monitored internal flow rate. Sensor performance was characterized in anticipation of future studies with real-time feedback control of focal delivery. The microfluidic system was characterized by determining the fluid delivery rates through the pores and concentration profiles of agents delivered. Finally, focal delivery to rat retinal tissue was demonstrated.
Bibliography:http://dx.doi.org/10.1016/j.snb.2010.12.019
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2010.12.019