Single Nucleotide Polymorphisms of DNA Base-excision Repair Genes (APE1, OGG1 and XRCC1) Associated with Breast Cancer Risk in a Chinese Population

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 15; no. 3; pp. 1133 - 1140
• Main Authors: Luo, Hao, Li, Zheng, Qing, Yi, Zhang, Shi-Heng, Peng, Yu, Li, Qing, Wang, Dong
• Format: Journal Article
• Language: English
• Published: Thailand 01.01.2014
• Subjects: Breast Neoplasms - genetics; Carcinogenesis - genetics; Case-Control Studies; China; DNA Damage - genetics; DNA Glycosylases - genetics; DNA Repair - genetics; DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics; DNA-Binding Proteins - genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Multivariate Analysis; Polymorphism, Single Nucleotide; Postmenopause; Risk; X-ray Repair Cross Complementing Protein 1

Altered DNA repair capacity can result in increased susceptibility to cancer. The base excision repair (BER) pathway effectively removes DNA damage caused by ionizing radiation and reactive oxidative species (ROS). In the current study, we analyzed the possible relation of polymorphisms in BER genes...