Predictive value of phosphorylated axonal neurofilament subunit H for clinical outcome in patients with acute intracerebral hemorrhage

• Published in: Clinica chimica acta Vol. 424; pp. 182 - 186
• Main Authors: Cai, Jian-Yong, Lu, Chuan, Chen, Mao-Hua, Ba, Hua-Jun, Chen, Xian-Dong, Lin, Jian-Hu, Sun, Jun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 23.09.2013
• Subjects: Acute Disease; Aged; Biomarkers - blood; Case-Control Studies; Cerebral Hemorrhage - blood; Cerebral Hemorrhage - diagnosis; Cerebral Hemorrhage - mortality; Disease Progression; Early neurological deterioration; Female; Humans; Intracerebral hemorrhage; Male; Middle Aged; Neurofilament; Neurofilament Proteins - blood; Outcome; Phosphorylation; Predictive Value of Tests; Prognosis; ROC Curve; Stroke; Survival Analysis; NIHSS; Neurofilament; Stroke; Outcome; pNF-H; Early neurological deterioration; Intracerebral hemorrhage; mRS; modified Rankin Scale; National Institutes of Health Stroke Scale; Phosphorylated axonal neurofilament subunit H

Phosphorylated axonal neurofilament subunit H (pNF-H) is a biomarker of axonal injury. We investigated whether plasma pNF-H concentrations were associated with 6-month clinical outcomes and early neurological deterioration (END) of patients with acute intracerebral hemorrhage. Plasma pNF-H concentra...