Glucose-conjugated platinum(IV) complexes as tumor-targeting agents: design, synthesis and biological evaluation

• Published in: Bioorganic & medicinal chemistry Vol. 27; no. 8; pp. 1639 - 1645
• Main Authors: Wang, Haifeng, Yang, Xiande, Zhao, Caili, Wang, Peng George, Wang, Xin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.04.2019
• Subjects: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antitumor; Apoptosis - drug effects; Cell Line, Tumor; Cell Survival - drug effects; Cisplatin - pharmacology; Coordination Complexes - chemistry; Coordination Complexes - pharmacology; Drug Design; Drug Screening Assays, Antitumor; Glucose - chemistry; Glucose Transport Proteins, Facilitative - antagonists & inhibitors; Glucose Transport Proteins, Facilitative - metabolism; Glucose transporter; Glycosylation; Humans; Oxaliplatin - pharmacology; Phlorhizin - chemistry; Phlorhizin - metabolism; Phlorhizin - pharmacology; Platinum - chemistry; Platinum(IV) complexes; Tumor targeting; Glucose transporter; Glycosylation; Tumor targeting; Platinum(IV) complexes; Antitumor

[Display omitted] A new series of glucose-conjugated Pt(IV) complexes that target tumor-specific glucose transporters (GLUTs) was designed, synthesized, and evaluated for their anticancer activities. All six compounds, namely, A1-A6, exhibited increased cytotoxicity that were almost six fold higher...