Novel Mutations of the PARP-1 Gene Associated with Colorectal Cancer in the Saudi Population

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 15; no. 8; pp. 3667 - 3673
• Main Authors: Alshammari, Atika Hazzaa, Shalaby, Manal Aly, Alanazi, Mohammad Saud, Saeed, Hesham Mahmoud
• Format: Journal Article
• Language: English
• Published: Thailand 01.01.2014
• Subjects: Carcinoma - genetics; Case-Control Studies; Colorectal Neoplasms - genetics; Exons - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases - genetics; Polymorphism, Single Nucleotide; Saudi Arabia

Colorectal cancer (CRC) is the third most common type of cancers and the fourth leading cause of death worldwide. In Saudi Arabia, CRC accounts for 8.5% of all tumors; it ranks first among all cancers in males and third among females. The aim of this study was to link between different PARP-1 mutati...