Xenotransplantation experiments in brain-dead human subjects–A critical appraisal

• Published in: American journal of transplantation Vol. 24; no. 4; pp. 520 - 525
• Main Authors: Cooper, David K.C., Kobayashi, Takaaki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2024
• Subjects: Animals; Animals, Genetically Modified; Brain; Brain Death; decedents; Graft Rejection - etiology; Graft Survival; Heterografts; Humans; kidney; Swine; Transplantation, Heterologous - methods; xenotransplantation; GTKO; kidney; NHP; brain death; TKO; xenotransplantation; decedents

Brain-dead human subjects (decedents) were recently introduced as a potential preclinical experimental model in xenotransplantation. Brain death is associated with major pathophysiological changes, eg, structural injury and cell infiltration in vital organs, and major hormonal, metabolic, inflammato...