Galectin-1 and galectin-3: Plausible tumour markers for oral squamous cell carcinoma and suitable targets for screening high-risk population

• Published in: Clinica chimica acta Vol. 442; pp. 13 - 21
• Main Authors: Aggarwal, Sadhna, Sharma, Suresh C., Das, Satya N.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.03.2015
• Subjects: Adult; Aged; Aged, 80 and over; Biomarker; Biomarkers, Tumor - blood; Biomarkers, Tumor - genetics; Carcinogenesis; Carcinoma, Squamous Cell - blood; Carcinoma, Squamous Cell - diagnosis; Carcinoma, Squamous Cell - pathology; Case-Control Studies; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cloning, Molecular; Female; Galectin 1 - blood; Galectin 1 - genetics; Galectin 3 - blood; Galectin 3 - genetics; Galectins; Gene Expression Regulation, Neoplastic; Humans; Male; Mass Screening; Middle Aged; Mouth Neoplasms - blood; Mouth Neoplasms - diagnosis; Mouth Neoplasms - pathology; Oral cancer; Prognosis; Risk; Risk association; RNA, Messenger - genetics; RNA, Messenger - metabolism; ROC; Tumour growth; Vascular Endothelial Growth Factor A - blood; Young Adult; peripheral blood mononuclear cells; Biomarker; Oral cancer; ROC; oral squamous cell carcinoma; Risk association; MTT; radioimmunoprecipitaion assay; vascular endothelial growth factor; Galectins; Dulbecco's modified eagle medium; galectin-3; quantitative real-time polymerase chain reaction; galectin-1; glyceraldehyde 3-phosphate dehydrogenase; Tumour growth

Galectins are a family of carbohydrate binding proteins that regulate several cellular functions such as growth, migration, adhesion and apoptosis. We investigated the expression of galectin (gal)-1 and galectin (gal)-3 in patients with oral squamous cell carcinoma (OSCC) and observed their effects...