Tools of gene transfer applied to the intracellular delivery of non-nucleic acid polyanionic drugs

• Published in: Chemical communications (Cambridge, England) Vol. 52; no. 5; pp. 889 - 891
• Main Authors: Kryger, Mille B L, Pedersen, Søren L, Wohl, Benjamin M, Zelikin, Alexander N
• Format: Journal Article
• Language: English
• Published: England 01.01.2016
• Subjects: Acrylic Resins - chemistry; Acrylic Resins - pharmacology; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - chemistry; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; Antiviral Agents - administration & dosage; Antiviral Agents - chemistry; Antiviral Agents - pharmacology; Cell Survival - drug effects; Drug delivery systems; Drug Delivery Systems - methods; Drugs; Gene Transfer Techniques; Genes; Humans; Lipopolysaccharides - antagonists & inhibitors; Lipopolysaccharides - pharmacology; Macrophages - drug effects; Macrophages - metabolism; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - biosynthesis; Ribavirin - administration & dosage; Ribavirin - chemistry; Ribavirin - pharmacology; Transfection; Utilities
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/c5cc08011h

We report the first successful implementation of transfection agents to facilitate the delivery of non-nucleic acid based anti-inflammatory and anti-viral drugs. In doing so, we illustrate a new paradigm in the intracellular delivery of polyanionic drugs and also extend the scope and utility of successful tools of gene transfer into a new area of biomedical research.