JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients

• Published in: Acta biochimica et biophysica Sinica Vol. 49; no. 3; pp. 208 - 215
• Main Authors: Ji, Juan, Wu, Yeqing, Meng, Yan, Zhang, Lijuan, Feng, Guijuan, Xia, Yunfei, Xue, Wenrong, Zhao, Shuyang, Gu, Zhifeng, Shao, Xiaoyi
• Format: Journal Article
• Language: English
• Published: China 01.03.2017
• Subjects: Adolescent; Adult; Bone Marrow - metabolism; Bone Marrow - pathology; Case-Control Studies; Cell Proliferation; Cells, Cultured; Cellular Senescence; Female; Humans; JAK-STAT; Janus Kinase 2 - metabolism; Lupus Erythematosus, Systemic - metabolism; Lupus Erythematosus, Systemic - pathology; Male; Mesenchymal Stromal Cells - metabolism; Mesenchymal Stromal Cells - pathology; Phosphorylation; Signal Transduction; STAT3 Transcription Factor - metabolism; Young Adult; β-半乳糖苷酶; 介导; 信号通路; 患者; 系统性红斑狼疮; 细胞衰老; 骨髓间充质干细胞; senescence; JAK-STAT signaling; IFN-γ; systemic lupus erythematosus; mesenchymal stem cells

Previous studies have revealed that bone marrow-mesenchymal stem cells （BM-MSCs） from systemic lupus erythematosus （SLE） patients exhibited early signs of senescence, which may participate in the development of SLE. However, the molecular mechanisms about this phenomenon have not been fully elucidat...