Changes in non-fasting concentrations of blood lipids after a daily Chinese breakfast in overweight subjects without fasting hypertriglyceridemia

• Published in: Clinica chimica acta Vol. 490; pp. 147 - 153
• Main Authors: Tian, Feng, Xiang, Qun-yan, Zhang, Ming-yu, Chen, Yan-qiao, Lin, Qiu-zhen, Wen, Tie, Liu, Ling
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2019
• Subjects: Hypertriglyceridemia; Non-fasting; Overweight; Remnant lipoproteins cholesterol; Triglyceride-rich lipoproteins; Non-fasting; Triglyceride-rich lipoproteins; Remnant lipoproteins cholesterol; Hypertriglyceridemia; Overweight
• ISSN: 0009-8981; 1873-3492; 1873-3492
• DOI: 10.1016/j.cca.2019.01.004

Overweight is always accompanied by hypertriglyceridemia (HTG), but the change in non-fasting triglyceride (TG) concentration in overweight subjects without postprandial hypertriglyceridemia was unknown. Concentrations of serum lipids were measured at 2 and 4 h in matched overweight (OW group, n = 54) and control subjects (CON group, n = 55) after a daily meal. Concentrations of remnant cholesterol and non-HDL cholesterol were calculated according to the formulas. The diagnostic criteria for non-fasting HTG were based on 2 different consensus statement. ROC curve was used to determine the pointcut of postprandial HTG. OW group had higher fasting concentrations of RC and non-HDL-C than CON group. Non-fasting concentrations of triglyceride and RC significantly increased in 2 groups while were higher in OW group (p < .05). The proportion of non-fasting HTG increased after a daily meal in OW group was significantly higher than the percentage of fasting HTG (p < .05). There was a significant correlation between the postprandial concentrations of TG and RC. Overweight subjects were more likely to develop non-fasting hypertriglyceridemia and higher concentrations of RC and non-HDL-C. Additionally, 2.0 mmol/l at 4 h after breakfast could be a pointcut value to detect changes in lipid profile of Chinese overweight people. •Overweight subjects were more likely to develop HTG after a Chinese daily diet.•The non-fasting diagnostic accuracy of HTG was compared by different standards.•2.0 mmol/L could be a better cut-point to diagnose non-fasting TG elevation.•The correlation between levels of TG and RC was highest at 4 h after breakfast.•4 h after a diet could be an ideal time to detect the levels of non-fasting lipids.