Molecular docking and virtual screening for novel protein tyrosine phosphatase 1B (PTP1B) inhibitors

• Published in: Bioinformation Vol. 8; no. 17; pp. 834 - 837
• Main Authors: Rao, Pasupuleti Sreenivasa, Muvva, Charuvaka, Geethanjali, Karli, Bastipati, Suresh Babu, Kalashikam, Rajitha
• Format: Journal Article
• Language: English
• Published: Singapore Biomedical Informatics 01.01.2012
• Subjects: Hypothesis; ADME-Tox; ZINC database; Virtual Screening; PTP1B; Lead-like

Protein tyrosine phosphatase 1B (PTP1B) functions as major negative regulator of insulin and leptin signaling pathways. In view of this, PTP1B is an significant target for drug development against cancer, diabetes and obesity. The aim of the current study is to identify PTP1B inhibitors by means of...