Cytotoxicity and pro-inflammatory effect of polystyrene nano-plastic and micro-plastic on RAW264.7 cells
Numerous studies have shown that exposure to micro- or nano-plastics led to the cell viability and function of macrophages in the intestine tissue might be one possible mechanism. This study investigated the cytotoxicity and pro-inflammatory effect of 80 nm polystyrene-nano-plastic (PS-NP) and 3 µm...
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| Published in | Toxicology (Amsterdam) Vol. 484; p. 153391 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
15.01.2023
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| Abstract | Numerous studies have shown that exposure to micro- or nano-plastics led to the cell viability and function of macrophages in the intestine tissue might be one possible mechanism. This study investigated the cytotoxicity and pro-inflammatory effect of 80 nm polystyrene-nano-plastic (PS-NP) and 3 µm PS-micro-plastic (PS-MP) on mouse macrophages RAW264.7 cells. Our results showed that exposure to PS-NP or PS-MP induced apoptosis of cells at 5 or 10 μg/mL, respectively. Besides, PS-NP enhanced the secretion of inflammatory cytokines (Tumor necrosis factor-α, Interleukin-6 and Interleukin-10) with the lowest effective concentration (LOEC) of 1, 0.01, and 0.01 μg/mL, respectively. PS-MP enhanced secretion of TNF-α and IL-10 with the LOEC of 1 and 0.01 μg/mL, respectively. We further studied the possible mechanisms of the effects of PS-NP or PS-MP on RAW264.7 cells. We found they might cause cytotoxicity and inflammatory effects by producing reactive oxygen species and nitric oxide in the cells. Accordingly, our results demonstrated that PS-NP and PS-MP had cytotoxicity and pro-inflammatory effect on macrophages, which might further lead to intestinal inflammation. Moreover, we revealed that the PS-NP had more potent adverse impacts on macrophages than PS-MP.
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•Nano-plastic and micro-plastic showed cytotoxicity on RAW264.7 cells.•Nano-plastic and micro-plastic showed pro-inflammatory effect on RAW264.7 cells.•Nano-plastic showed more potent adverse impacts on macrophages than micro-plastic.•The adverse effects might be due to the production of ROS and NO in the cells. |
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| AbstractList | Numerous studies have shown that exposure to micro- or nano-plastics led to the cell viability and function of macrophages in the intestine tissue might be one possible mechanism. This study investigated the cytotoxicity and pro-inflammatory effect of 80 nm polystyrene-nano-plastic (PS-NP) and 3 µm PS-micro-plastic (PS-MP) on mouse macrophages RAW264.7 cells. Our results showed that exposure to PS-NP or PS-MP induced apoptosis of cells at 5 or 10 μg/mL, respectively. Besides, PS-NP enhanced the secretion of inflammatory cytokines (Tumor necrosis factor-α, Interleukin-6 and Interleukin-10) with the lowest effective concentration (LOEC) of 1, 0.01, and 0.01 μg/mL, respectively. PS-MP enhanced secretion of TNF-α and IL-10 with the LOEC of 1 and 0.01 μg/mL, respectively. We further studied the possible mechanisms of the effects of PS-NP or PS-MP on RAW264.7 cells. We found they might cause cytotoxicity and inflammatory effects by producing reactive oxygen species and nitric oxide in the cells. Accordingly, our results demonstrated that PS-NP and PS-MP had cytotoxicity and pro-inflammatory effect on macrophages, which might further lead to intestinal inflammation. Moreover, we revealed that the PS-NP had more potent adverse impacts on macrophages than PS-MP.
[Display omitted]
•Nano-plastic and micro-plastic showed cytotoxicity on RAW264.7 cells.•Nano-plastic and micro-plastic showed pro-inflammatory effect on RAW264.7 cells.•Nano-plastic showed more potent adverse impacts on macrophages than micro-plastic.•The adverse effects might be due to the production of ROS and NO in the cells. Numerous studies have shown that exposure to micro- or nano-plastics led to the cell viability and function of macrophages in the intestine tissue might be one possible mechanism. This study investigated the cytotoxicity and pro-inflammatory effect of 80 nm polystyrene-nano-plastic (PS-NP) and 3 µm PS-micro-plastic (PS-MP) on mouse macrophages RAW264.7 cells. Our results showed that exposure to PS-NP or PS-MP induced apoptosis of cells at 5 or 10 μg/mL, respectively. Besides, PS-NP enhanced the secretion of inflammatory cytokines (Tumor necrosis factor-α, Interleukin-6 and Interleukin-10) with the lowest effective concentration (LOEC) of 1, 0.01, and 0.01 μg/mL, respectively. PS-MP enhanced secretion of TNF-α and IL-10 with the LOEC of 1 and 0.01 μg/mL, respectively. We further studied the possible mechanisms of the effects of PS-NP or PS-MP on RAW264.7 cells. We found they might cause cytotoxicity and inflammatory effects by producing reactive oxygen species and nitric oxide in the cells. Accordingly, our results demonstrated that PS-NP and PS-MP had cytotoxicity and pro-inflammatory effect on macrophages, which might further lead to intestinal inflammation. Moreover, we revealed that the PS-NP had more potent adverse impacts on macrophages than PS-MP. |
| ArticleNumber | 153391 |
| Author | Li, Fan Zhao, Fenqing Pan, Xuejun Wang, Xiaoxia Huang, Bin Liu, Kunqian Ren, Xiao-Min Hu, Huixiang Zhang, Pingping He, Huan |
| Author_xml | – sequence: 1 givenname: Xiaoxia surname: Wang fullname: Wang, Xiaoxia organization: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China – sequence: 2 givenname: Xiao-Min surname: Ren fullname: Ren, Xiao-Min email: 412656694@qq.com organization: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China – sequence: 3 givenname: Huan surname: He fullname: He, Huan organization: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China – sequence: 4 givenname: Fan surname: Li fullname: Li, Fan organization: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China – sequence: 5 givenname: Kunqian surname: Liu fullname: Liu, Kunqian organization: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China – sequence: 6 givenname: Fenqing surname: Zhao fullname: Zhao, Fenqing organization: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China – sequence: 7 givenname: Huixiang surname: Hu fullname: Hu, Huixiang organization: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China – sequence: 8 givenname: Pingping surname: Zhang fullname: Zhang, Pingping organization: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China – sequence: 9 givenname: Bin surname: Huang fullname: Huang, Bin organization: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China – sequence: 10 givenname: Xuejun surname: Pan fullname: Pan, Xuejun email: xjpan@kust.edu.cn organization: Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36503103$$D View this record in MEDLINE/PubMed |
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| Keywords | Micro/nano-plastic Intestinal inflammation Inflammatory cytokines Macrophages Apoptosis |
| Language | English |
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| SubjectTerms | Animals Apoptosis Cytokines Inflammatory cytokines Intestinal inflammation Macrophages Mice Micro/nano-plastic Microplastics Polystyrenes - toxicity RAW 264.7 Cells Tumor Necrosis Factor-alpha |
| Title | Cytotoxicity and pro-inflammatory effect of polystyrene nano-plastic and micro-plastic on RAW264.7 cells |
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