Analysis of serum genome-wide microRNAs for breast cancer detection

• Published in: Clinica chimica acta Vol. 413; no. 13-14; pp. 1058 - 1065
• Main Authors: Wu, Qian, Wang, Chao, Lu, Zuhong, Guo, Li, Ge, Qinyu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 11.07.2012
• Subjects: Biomarker; Breast cancer; Breast Neoplasms - blood; Breast Neoplasms - diagnosis; Breast Neoplasms - genetics; Cell Line, Tumor; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic - genetics; Genome-Wide Association Study; Humans; MicroRNA; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; Next-generation sequencing; ROC Curve; Serum; Tissue; Tissue; Serum; Biomarker; Breast cancer; MicroRNA; Next-generation sequencing

Among methods for profiling levels of miRNAs, next-generation sequencing (NGS) has an effective one for genome-wide profiles, which not only can accurately quantify known miRNAs expression, but also discovery novel miRNAs. In this paper, we investigated that whether specific miRNAs were co-expressed...