PERK/eIF2α contributes to changes of insulin signaling in HepG2 cell induced by intermittent hypoxia

• Published in: Life sciences (1973) Vol. 181; pp. 17 - 22
• Main Authors: Yi, Huahua, Gu, Chenjuan, Li, Min, Zhang, Zhiguo, Li, Qingyun, Feng, Jing, Zhou, Jun, Du, Juan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.07.2017
• Subjects: AKT; Blotting, Western; Butylamines - pharmacology; eIF-2 Kinase - metabolism; eIF2α; Endoplasmic Reticulum Stress - physiology; ER stress; Gene Expression Regulation - genetics; Glucose - metabolism; Hep G2 Cells; Humans; Hypoxia - complications; Insulin - administration & dosage; Insulin - metabolism; Intermittent hypoxia; PERK; Phosphorylation; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction - physiology; Sleep Apnea, Obstructive - physiopathology; Time Factors; Up-Regulation - genetics; Intermittent hypoxia; eIF2α; ER stress; AKT; PERK

Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with abnormal glucose metabolism. Nowadays, endoplasmic reticulum (ER) stress emerges as an important mechanism underlying the development of type 2 diabetes mellitus (T2DM). However, it remains unclear that intermittent hypoxia (IH) co...