Insights into the anaphase-promoting complex: a molecular machine that regulates mitosis

• Published in: Current opinion in structural biology Vol. 29; pp. 1 - 9
• Main Authors: Chang, Leifu, Barford, David
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2014
• Subjects: Anaphase-Promoting Complex-Cyclosome - metabolism; Cell Cycle Proteins - metabolism; F-Box Proteins - metabolism; Humans; M Phase Cell Cycle Checkpoints; Mitosis; Multiprotein Complexes - metabolism; Protein Conformation; Protein Processing, Post-Translational; Proteolysis; Substrate Specificity; Ubiquitin - metabolism; Ubiquitin-Protein Ligases - metabolism; Ubiquitination

•Assignment of the complete secondary structure and subunit identification of the APC/C.•Mechanism of D box and KEN box recognition by APC/C-coactivator complexes.•Mechanism of stimulation of APC/C E3 ligase reaction by coactivator.•Principles of APC/C inhibition by regulators through blocking degro...