Validated spectroscopic methods for determination of anti-histaminic drug azelastine in pure form: Analytical application for quality control of its pharmaceutical preparations

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 191; pp. 413 - 420
• Main Authors: El-Masry, Amal A., Hammouda, Mohammed E.A., El-Wasseef, Dalia R., El-Ashry, Saadia M.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.02.2018
• Subjects: Azelastine HCl (AZL); Binary complex; Difference spectroscopy; Eosin; Spectral difference; Spectral difference; Azelastine HCl (AZL); Binary complex; Difference spectroscopy; Eosin

Two simple, sensitive, rapid, validated and cost effective spectroscopic methods were established for quantification of antihistaminic drug azelastine (AZL) in bulk powder as well as in pharmaceutical dosage forms. In the first method (A) the absorbance difference between acidic and basic solutions...