Transcriptional regulation and therapeutic potential of cyclin-dependent kinase 9 (CDK9) in sarcoma

• Published in: Biochemical pharmacology Vol. 226; p. 116342
• Main Authors: Walker, Robert L., Hornicek, Francis J., Duan, Zhenfeng
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.08.2024
• Subjects: CDK9; RNAPII; Sarcoma; Small molecular inhibitors; Transcription; CTR; PP; TFs; Ser; 7SK snRNP; Transcription; MCL-1; XIAP; P-TEFb; PDB; BCL-2; NF-κB; NELF; PP4R2; MSC; RNAPII; Small molecular inhibitors; BRD4; Thr; MEF2; HSP90; EEC; OS; Sarcoma; MyoD; STAT3; PIC; DRB-DSIF; CDK9; DHFR; SEC; KOW; TSS; BAX; MALAT1

[Display omitted] Sarcomas include various subtypes comprising two significant groups – soft tissue and bone sarcomas. Although the survival rate for some sarcoma subtypes has improved over time, the current methods of treatment remain efficaciously limited, as recurrent, and metastatic diseases rem...