Effects of uric acid-lowering therapy on renal outcomes: a systematic review and meta-analysis

• Published in: Nephrology, dialysis, transplantation Vol. 29; no. 2; pp. 406 - 413
• Main Authors: Bose, Bhadran, Badve, Sunil V., Hiremath, Swapnil S., Boudville, Neil, Brown, Fiona G., Cass, Alan, de Zoysa, Janak R., Fassett, Robert G., Faull, Randall, Harris, David C., Hawley, Carmel M., Kanellis, John, Palmer, Suetonia C., Perkovic, Vlado, Pascoe, Elaine M., Rangan, Gopala K., Walker, Robert J., Walters, Giles, Johnson, David W.
• Format: Journal Article
• Language: English
• Published: England 01.02.2014
• Subjects: Allopurinol - therapeutic use; Disease Progression; Gout Suppressants - therapeutic use; Humans; Renal Insufficiency, Chronic - blood; Renal Insufficiency, Chronic - drug therapy; Uric Acid - blood; clinical trial; chronic kidney disease; kidney function test; uric acid; renal dialysis

Non-randomized studies suggest an association between serum uric acid levels and progression of chronic kidney disease (CKD). The aim of this systematic review is to summarize evidence from randomized controlled trials (RCTs) concerning the benefits and risks of uric acid-lowering therapy on renal o...