Calibration of activity readings from radiopharmaceuticals with impurities
Accurately determining the amount of a radionuclide actually administered to a patient is an important aspect of quality control in nuclear medicine. In this study, in order to accurately assess the “apparent” radioactivities of radionuclides with impurities by a dose calibrator, two methods, (1) cu...
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| Published in | Journal of radioanalytical and nuclear chemistry Vol. 290; no. 1; pp. 153 - 157 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Dordrecht
Springer Netherlands
01.10.2011
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| Abstract | Accurately determining the amount of a radionuclide actually administered to a patient is an important aspect of quality control in nuclear medicine. In this study, in order to accurately assess the “apparent” radioactivities of radionuclides with impurities by a dose calibrator, two methods, (1) curve fitting, and (2) relative sensitivities calculation, have been employed to determine the parameter,
M
(relative response). From the comparisons between the measurement and re-calculated radioactivity using the
M
values, each method was found to have its own advantage and disadvantage, depending upon the fraction ratio of the impurity as well as the energy level of the impurity’s photons. This study might be helpful for improving the assessment of radiopharmaceuticals’ “true” activity and its “apparent” activity measured by a dose calibrator. |
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| AbstractList | Accurately determining the amount of a radionuclide actually administered to a patient is an important aspect of quality control in nuclear medicine. In this study, in order to accurately assess the 'apparent' radioactivities of radionuclides with impurities by a dose calibrator, two methods, (1) curve fitting, and (2) relative sensitivities calculation, have been employed to determine the parameter, M (relative response). From the comparisons between the measurement and re-calculated radioactivity using the M values, each method was found to have its own advantage and disadvantage, depending upon the fraction ratio of the impurity as well as the energy level of the impurity's photons. This study might be helpful for improving the assessment of radiopharmaceuticals' 'true' activity and its 'apparent' activity measured by a dose calibrator. Accurately determining the amount of a radionuclide actually administered to a patient is an important aspect of quality control in nuclear medicine. In this study, in order to accurately assess the “apparent” radioactivities of radionuclides with impurities by a dose calibrator, two methods, (1) curve fitting, and (2) relative sensitivities calculation, have been employed to determine the parameter, M (relative response). From the comparisons between the measurement and re-calculated radioactivity using the M values, each method was found to have its own advantage and disadvantage, depending upon the fraction ratio of the impurity as well as the energy level of the impurity’s photons. This study might be helpful for improving the assessment of radiopharmaceuticals’ “true” activity and its “apparent” activity measured by a dose calibrator. |
| Author | Chen, Ching-Kuei Shen, Lie-Hang Chang, Kwo-Ping |
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| Cites_doi | 10.1118/1.1333411 10.1016/S0969-8043(97)10091-4 10.1016/S0969-8043(02)00179-3 10.1016/S0969-8043(97)00049-3 10.1016/S0969-8043(98)00166-3 10.1016/j.apradiso.2005.05.051 |
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| Copyright | Akadémiai Kiadó, Budapest, Hungary 2011 |
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| Keywords | Dose calibrator Relative response Apparent radioactivities Impurities |
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| References | Colle, Zimmerman, Soares, Coursey (CR3) 1999; 50 Bonardi, Groppi, Birattari (CR7) 2002; 57 Johnston, Colombetti, Baker, Pinsky (CR1) 1980; XIX CR4 CR5 Golas (CR6) 1998; 49 Smith (CR2) 2001; 28 Santry (CR9) 1998; 49 Oropesa, Hernandez, Serra, Varela (CR8) 2005; 63 MF Smith (1169_CR2) 2001; 28 P Oropesa (1169_CR8) 2005; 63 D Santry (1169_CR9) 1998; 49 R Colle (1169_CR3) 1999; 50 1169_CR4 1169_CR5 AS Johnston (1169_CR1) 1980; XIX M Bonardi (1169_CR7) 2002; 57 DB Golas (1169_CR6) 1998; 49 |
| References_xml | – volume: XIX start-page: 1 year: 1980 end-page: 6 ident: CR1 article-title: Dose calibrator readings due to radionuclidic impurities found in radiopharmaceuticals publication-title: Nucl Med contributor: fullname: Pinsky – volume: 28 start-page: 36 year: 2001 end-page: 45 ident: CR2 article-title: Device-dependent activity estimation and decay correction of radionuclide mixtures with application to Tc-94m PET studies publication-title: Med Phys doi: 10.1118/1.1333411 contributor: fullname: Smith – ident: CR5 – volume: 49 start-page: 1453 year: 1998 end-page: 1458 ident: CR9 article-title: The Canadian experience in performing accuracy checks on administered doses of radiopharmaceuticals publication-title: Appl Radiat Isot doi: 10.1016/S0969-8043(97)10091-4 contributor: fullname: Santry – volume: 57 start-page: 647 year: 2002 end-page: 655 ident: CR7 article-title: A rapid improved method for gamma-spectrometric determination of Tl impurities in [ Tl]-labelled radiopharmaceuticals publication-title: Appl Radiat Isot doi: 10.1016/S0969-8043(02)00179-3 contributor: fullname: Birattari – ident: CR4 – volume: 49 start-page: 329 year: 1998 end-page: 334 ident: CR6 article-title: NIST radiopharmaceutical standard reference materials and NEI/NIST radiopharmaceutical measurement assurance program publication-title: Appl Radiat Isot doi: 10.1016/S0969-8043(97)00049-3 contributor: fullname: Golas – volume: 50 start-page: 835 year: 1999 end-page: 841 ident: CR3 article-title: Determination of a calibrator factor for the non-destructive assay of Guidant P brachytherapy sources publication-title: Appl Radiat Isot doi: 10.1016/S0969-8043(98)00166-3 contributor: fullname: Coursey – volume: 63 start-page: 493 year: 2005 end-page: 503 ident: CR8 article-title: Comparisons of activity measurements with radionuclide calibrators—a tool for quality assessment and improvement in nuclear medicine publication-title: Appl Radiat Isot doi: 10.1016/j.apradiso.2005.05.051 contributor: fullname: Varela – volume: 63 start-page: 493 year: 2005 ident: 1169_CR8 publication-title: Appl Radiat Isot doi: 10.1016/j.apradiso.2005.05.051 contributor: fullname: P Oropesa – ident: 1169_CR5 – ident: 1169_CR4 – volume: 50 start-page: 835 year: 1999 ident: 1169_CR3 publication-title: Appl Radiat Isot doi: 10.1016/S0969-8043(98)00166-3 contributor: fullname: R Colle – volume: 57 start-page: 647 year: 2002 ident: 1169_CR7 publication-title: Appl Radiat Isot doi: 10.1016/S0969-8043(02)00179-3 contributor: fullname: M Bonardi – volume: XIX start-page: 1 year: 1980 ident: 1169_CR1 publication-title: Nucl Med contributor: fullname: AS Johnston – volume: 28 start-page: 36 year: 2001 ident: 1169_CR2 publication-title: Med Phys doi: 10.1118/1.1333411 contributor: fullname: MF Smith – volume: 49 start-page: 329 year: 1998 ident: 1169_CR6 publication-title: Appl Radiat Isot doi: 10.1016/S0969-8043(97)00049-3 contributor: fullname: DB Golas – volume: 49 start-page: 1453 year: 1998 ident: 1169_CR9 publication-title: Appl Radiat Isot doi: 10.1016/S0969-8043(97)10091-4 contributor: fullname: D Santry |
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| SubjectTerms | Calibration Chemistry Chemistry and Materials Science Curve fitting Diagnostic Radiology Hadrons Heavy Ions Impurities Inorganic Chemistry Mathematical analysis Nuclear Chemistry Nuclear medicine Nuclear Physics Photons Physical Chemistry Radioactivity |
| Title | Calibration of activity readings from radiopharmaceuticals with impurities |
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