Chronic D-galactose administration induces natural aging characteristics, in rat’s brain and heart
We aimed to investigate the effect of chronic D-galactose exposure on the mimicking of natural aging processes based upon the hallmarks of aging. Seven-week-old male Wistar rats (n = 12) were randomly assigned to receive either normal saline solution as a vehicle (n = 6) or 150 mg/kg/day of D-galact...
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Published in | Toxicology (Amsterdam) Vol. 492; p. 153553 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
15.06.2023
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Abstract | We aimed to investigate the effect of chronic D-galactose exposure on the mimicking of natural aging processes based upon the hallmarks of aging. Seven-week-old male Wistar rats (n = 12) were randomly assigned to receive either normal saline solution as a vehicle (n = 6) or 150 mg/kg/day of D-galactose subcutaneously for 28 weeks. Seventeen-month-old rats (n = 6) were also included as the chronologically aged controls. At the end of week 28 of the experiment (when the rats reach 35 weeks old and 24 months old), all rats were sacrificed for brain and heart collection. Our results showed that chronic D-galactose exposure mimicked natural aging characteristics of the brain and the heart in terms of deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, and functional impairment. All of which highlight the potential of D-galactose as a substance for inducing brain and cardiac aging in animal experiments.
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•D-galactose mimics natural aging of the brain based upon antagonistic and integrative hallmarks of aging.•D-galactose mimics natural aging of the heart based upon antagonistic and integrative hallmarks of aging.•D-galactose is a suitable substance for induction of brain and cardiac aging in animal experiments. |
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AbstractList | We aimed to investigate the effect of chronic D-galactose exposure on the mimicking of natural aging processes based upon the hallmarks of aging. Seven-week-old male Wistar rats (n = 12) were randomly assigned to receive either normal saline solution as a vehicle (n = 6) or 150 mg/kg/day of D-galactose subcutaneously for 28 weeks. Seventeen-month-old rats (n = 6) were also included as the chronologically aged controls. At the end of week 28 of the experiment (when the rats reach 35 weeks old and 24 months old), all rats were sacrificed for brain and heart collection. Our results showed that chronic D-galactose exposure mimicked natural aging characteristics of the brain and the heart in terms of deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, and functional impairment. All of which highlight the potential of D-galactose as a substance for inducing brain and cardiac aging in animal experiments. We aimed to investigate the effect of chronic D-galactose exposure on the mimicking of natural aging processes based upon the hallmarks of aging. Seven-week-old male Wistar rats (n = 12) were randomly assigned to receive either normal saline solution as a vehicle (n = 6) or 150 mg/kg/day of D-galactose subcutaneously for 28 weeks. Seventeen-month-old rats (n = 6) were also included as the chronologically aged controls. At the end of week 28 of the experiment (when the rats reach 35 weeks old and 24 months old), all rats were sacrificed for brain and heart collection. Our results showed that chronic D-galactose exposure mimicked natural aging characteristics of the brain and the heart in terms of deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, and functional impairment. All of which highlight the potential of D-galactose as a substance for inducing brain and cardiac aging in animal experiments. [Display omitted] •D-galactose mimics natural aging of the brain based upon antagonistic and integrative hallmarks of aging.•D-galactose mimics natural aging of the heart based upon antagonistic and integrative hallmarks of aging.•D-galactose is a suitable substance for induction of brain and cardiac aging in animal experiments. |
ArticleNumber | 153553 |
Author | Chunchai, Titikorn Kongkaew, Aphisek Arunsak, Busarin Chattipakorn, Nipon Nawara, Wichwara Pantiya, Patcharapong Ongnok, Benjamin Thonusin, Chanisa Chattipakorn, Siriporn C |
Author_xml | – sequence: 1 givenname: Patcharapong surname: Pantiya fullname: Pantiya, Patcharapong organization: Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand – sequence: 2 givenname: Chanisa surname: Thonusin fullname: Thonusin, Chanisa organization: Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand – sequence: 3 givenname: Benjamin surname: Ongnok fullname: Ongnok, Benjamin organization: Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand – sequence: 4 givenname: Titikorn surname: Chunchai fullname: Chunchai, Titikorn organization: Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand – sequence: 5 givenname: Aphisek surname: Kongkaew fullname: Kongkaew, Aphisek organization: Research Administration Section, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand – sequence: 6 givenname: Wichwara surname: Nawara fullname: Nawara, Wichwara organization: Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand – sequence: 7 givenname: Busarin surname: Arunsak fullname: Arunsak, Busarin organization: Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand – sequence: 8 givenname: Nipon surname: Chattipakorn fullname: Chattipakorn, Nipon organization: Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand – sequence: 9 givenname: Siriporn C surname: Chattipakorn fullname: Chattipakorn, Siriporn C email: siriporn.c@cmu.ac.th, scchattipakorn@gmail.com organization: Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand |
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Keywords | Aging Natural aging Neurodegenerative disease Cardiovascular disease D-galactose Hallmarks of aging |
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Snippet | We aimed to investigate the effect of chronic D-galactose exposure on the mimicking of natural aging processes based upon the hallmarks of aging.... |
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StartPage | 153553 |
SubjectTerms | Aging Aging - physiology Animals Brain Cardiovascular disease Cellular Senescence D-galactose Galactose - toxicity Hallmarks of aging Male Natural aging Neurodegenerative disease Rats Rats, Wistar |
Title | Chronic D-galactose administration induces natural aging characteristics, in rat’s brain and heart |
URI | https://dx.doi.org/10.1016/j.tox.2023.153553 https://www.ncbi.nlm.nih.gov/pubmed/37225035 https://search.proquest.com/docview/2819279964 |
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