Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response

• Published in: Journal of molecular biology Vol. 427; no. 23; pp. 3628 - 3645
• Main Authors: Rybtke, Morten, Hultqvist, Louise Dahl, Givskov, Michael, Tolker-Nielsen, Tim
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 20.11.2015
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; antimicrobial tolerance; biofilm; Biofilms - drug effects; Chronic Disease; Cystic Fibrosis - microbiology; Extracellular Matrix - chemistry; Foreign Bodies - microbiology; Humans; Immune Evasion; Male; Otitis Media - microbiology; Prostatitis - microbiology; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - immunology; Pseudomonas aeruginosa - pathogenicity; Pseudomonas aeruginosa - physiology; Pseudomonas Infections - drug therapy; Pseudomonas Infections - microbiology; structure; Wound Infection - microbiology; PMN; COM; QS; RSCV; CF; ROS; biofilm; Pseudomonas aeruginosa; eDNA; NET; antimicrobial tolerance; structure

Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in b...