Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response

Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in b...

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Published inJournal of molecular biology Vol. 427; no. 23; pp. 3628 - 3645
Main Authors Rybtke, Morten, Hultqvist, Louise Dahl, Givskov, Michael, Tolker-Nielsen, Tim
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 20.11.2015
Subjects
Animals
Anti-Bacterial Agents - pharmacology
antimicrobial tolerance
biofilm
Biofilms - drug effects
Chronic Disease
Cystic Fibrosis - microbiology
Extracellular Matrix - chemistry
Foreign Bodies - microbiology
Humans
Immune Evasion
Male
Otitis Media - microbiology
Prostatitis - microbiology
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - immunology
Pseudomonas aeruginosa - pathogenicity
Pseudomonas aeruginosa - physiology
Pseudomonas Infections - drug therapy
Pseudomonas Infections - microbiology
structure
Wound Infection - microbiology
PMN
COM
QS
RSCV
CF
ROS
biofilm
Pseudomonas aeruginosa
eDNA
NET
antimicrobial tolerance
structure
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Abstract Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in biofilm infection microbiology, biofilm formation mechanisms and biofilm-associated antimicrobial tolerance has become an important area in microbiology. Substantial knowledge about biofilm formation mechanisms, biofilm-associated antimicrobial tolerance and immune evasion mechanisms has been obtained through work with biofilms grown in in vitro experimental setups, and the relevance of this information in the context of chronic infections is being investigated by the use of animal models of infection. Because our current in vitro experimental setups and animal models have limitations, new advanced in vitro models developed with knowledge about the chemical landscape at infectious sites are needed. Pseudomonas aeruginosa biofilm in a chronic wound. The presence of the biofilm causes inflammation and is thought to keep the wound in an inflammatory that prevents healing. The arrows point to the wound surface. The scale bar corresponds to 30μm. [Display omitted] •Infections caused by microbial biofilms are a significant socio-economic burden that implicates hospitalization, patient suffering, lost employment, and reduced life quality.•Because the use of conventional antimicrobial compounds in many cases cannot eradicate biofilm infections, there is an urgent need to develop alternative measures to combat biofilms.•Research on biofilm infection microbiology, biofilm formation mechanisms, and biofilm-associated antimicrobial tolerance has come to the fore during the last two decades.•In the present article we review some of this research with a focus on the biofilm model organism P. aeruginosa.
AbstractList Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in biofilm infection microbiology, biofilm formation mechanisms and biofilm-associated antimicrobial tolerance has become an important area in microbiology. Substantial knowledge about biofilm formation mechanisms, biofilm-associated antimicrobial tolerance and immune evasion mechanisms has been obtained through work with biofilms grown in in vitro experimental setups, and the relevance of this information in the context of chronic infections is being investigated by the use of animal models of infection. Because our current in vitro experimental setups and animal models have limitations, new advanced in vitro models developed with knowledge about the chemical landscape at infectious sites are needed.
Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of tissue-associated and implant-associated recalcitrant human infections. With a need for novel anti-biofilm treatment strategies, research in biofilm infection microbiology, biofilm formation mechanisms and biofilm-associated antimicrobial tolerance has become an important area in microbiology. Substantial knowledge about biofilm formation mechanisms, biofilm-associated antimicrobial tolerance and immune evasion mechanisms has been obtained through work with biofilms grown in in vitro experimental setups, and the relevance of this information in the context of chronic infections is being investigated by the use of animal models of infection. Because our current in vitro experimental setups and animal models have limitations, new advanced in vitro models developed with knowledge about the chemical landscape at infectious sites are needed. Pseudomonas aeruginosa biofilm in a chronic wound. The presence of the biofilm causes inflammation and is thought to keep the wound in an inflammatory that prevents healing. The arrows point to the wound surface. The scale bar corresponds to 30μm. [Display omitted] •Infections caused by microbial biofilms are a significant socio-economic burden that implicates hospitalization, patient suffering, lost employment, and reduced life quality.•Because the use of conventional antimicrobial compounds in many cases cannot eradicate biofilm infections, there is an urgent need to develop alternative measures to combat biofilms.•Research on biofilm infection microbiology, biofilm formation mechanisms, and biofilm-associated antimicrobial tolerance has come to the fore during the last two decades.•In the present article we review some of this research with a focus on the biofilm model organism P. aeruginosa.
Author Hultqvist, Louise Dahl
Rybtke, Morten
Tolker-Nielsen, Tim
Givskov, Michael
Author_xml – sequence: 1
  givenname: Morten
  surname: Rybtke
  fullname: Rybtke, Morten
  organization: Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark
– sequence: 2
  givenname: Louise Dahl
  surname: Hultqvist
  fullname: Hultqvist, Louise Dahl
  organization: Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark
– sequence: 3
  givenname: Michael
  surname: Givskov
  fullname: Givskov, Michael
  organization: Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark
– sequence: 4
  givenname: Tim
  surname: Tolker-Nielsen
  fullname: Tolker-Nielsen, Tim
  email: ttn@sund.ku.dk
  organization: Costerton Biofilm Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark
BackLink https://www.ncbi.nlm.nih.gov/pubmed/26319792$$D View this record in MEDLINE/PubMed
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COM
QS
RSCV
CF
ROS
biofilm
Pseudomonas aeruginosa
eDNA
NET
antimicrobial tolerance
structure
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Snippet Studies of biopsies from infectious sites, explanted tissue and medical devises have provided evidence that biofilms are the underlying cause of a variety of...
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SubjectTerms Animals
Anti-Bacterial Agents - pharmacology
antimicrobial tolerance
biofilm
Biofilms - drug effects
Chronic Disease
Cystic Fibrosis - microbiology
Extracellular Matrix - chemistry
Foreign Bodies - microbiology
Humans
Immune Evasion
Male
Otitis Media - microbiology
Prostatitis - microbiology
Pseudomonas aeruginosa
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - immunology
Pseudomonas aeruginosa - pathogenicity
Pseudomonas aeruginosa - physiology
Pseudomonas Infections - drug therapy
Pseudomonas Infections - microbiology
structure
Wound Infection - microbiology
Title Pseudomonas aeruginosa Biofilm Infections: Community Structure, Antimicrobial Tolerance and Immune Response
URI https://dx.doi.org/10.1016/j.jmb.2015.08.016
https://www.ncbi.nlm.nih.gov/pubmed/26319792
https://search.proquest.com/docview/1735905672
Volume 427
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