Surface screening, molecular modeling and in vitro studies on the interactions of aflatoxin M1 and human enzymes acetyl- and butyrylcholinesterase

• Published in: Chemico-biological interactions Vol. 308; pp. 113 - 119
• Main Authors: de Almeida, Joyce S.F.D., Cavalcante, Samir F.de A., Dolezal, Rafael, Kuca, Kamil, Musilek, Kamil, Jun, Daniel, França, Tanos C.C.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.08.2019
• Subjects: Acetylcholinesterase; Aflatoxin M1; Butyrylcholinesterase; Molecular modeling; Surface screening; BChE; PR; PAS; AFB1; Acetylcholinesterase; Molecular modeling; HssAChE; MD; RM1; L-BFGS; SS; ACPYPE; AChE; Aflatoxin M1; Surface screening; DTNB; RMSF; RMSD; Butyrylcholinesterase; ATC; BTC; PB; CAS; AFM1; HssBChE; MVD; SEM

Aflatoxin M1 (AFM1) is a mycotoxin produced by Aspergillus fungi and found in contaminated milk, breastfeed and dairy products, being highly toxic and carcinogenic to humans and other mammalian species. It is also produced in the human body as a metabolite of aflatoxin B1 (AFB1), one of the most tox...