Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin–induced diabetic nephropathy in mice

Rhizome of Ligusticum chuanxiong Hort. (Abbreviated as LC) is a frequently prescribed component in plenty of traditional Chinese medicine (TCM) formulas which are used to treat diabetic nephropathy (DN). The aims of the present study are to investigate the protective effect of the ethanol extract of...

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Published inJournal of ethnopharmacology Vol. 227; pp. 166 - 175
Main Authors Yang, Wen-Jing, Li, Yan-Ru, Gao, Hui, Wu, Xue-Yi, Wang, Xiao-Ling, Wang, Xiao-Ning, Xiang, Lan, Ren, Dong-Mei, Lou, Hong-Xiang, Shen, Tao
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 05.12.2018
Subjects
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antioxidants - pharmacology
Antioxidants - therapeutic use
Cell Line
Cell Survival - drug effects
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - pathology
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - pathology
Diabetic nephropathy
Humans
Ligusticum
Ligusticum chuanxiong
Male
Mice
Mice, Inbred C57BL
NF-E2-Related Factor 2 - metabolism
NF-kappa B - metabolism
NF-κB
Nrf2
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rhizome
ESRD
NO
COX-2
DI
DN
NF-κB
GFR
SF
Nrf2
STZ
iNOS
Diabetic nephropathy
NQO1
QR
IL
MQI
AEL
EEL
8-oxo-dG
ARE
TNF-α
TMP
LC
ROS
LGT
Ligusticum chuanxiong
FA
GCLM
ELISA
TCM
Online AccessGet full text

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Abstract Rhizome of Ligusticum chuanxiong Hort. (Abbreviated as LC) is a frequently prescribed component in plenty of traditional Chinese medicine (TCM) formulas which are used to treat diabetic nephropathy (DN). The aims of the present study are to investigate the protective effect of the ethanol extract of LC rhizome (EEL) against DN in vivo, evaluate its potential mechanism, and find the evidence supporting its enthopharmacological use as an anti-DN agent. Hepa 1c1c7 murine hepatoma cells, human breast carcinoma MDA-MB-231 cells, human renal glomerular endothelial cells (HRGEC), and RAW 264.7 murine macrophages were adopted to test the effects of EEL and its active constituents on inhibitions of oxidative stress and inflammation in vitro. A streptozotocin (STZ) -induced DN C57BL/6 mice model was established and used to investigate the preventive effect of EEL against DN in vivo. EEL demonstrated potential inhibitory effects against oxidative stress and inflammation in vitro. Using a STZ-induced DN mice model, it has been found that EEL treatment significantly prevented STZ-induced increases of urine production, urinary albumin excretion (UAE) and urine albumin-to-creatinine ratio (UACR), and markedly attenuated STZ-induced renal damages (e.g. glomerulosclerosis and fibrosis). The predominant bioactive constituents, Z-ligustilide (LGT), ferulic acid (FA), and tetramethylpyrazine (TMP), were inhibitors of oxidative stress and inflammation through acting with Nrf2 and NF-κB pathways. EEL attenuates structural and functional damages of kidney in STZ-induced DN model in vivo, which might be related to the functions of EEL on inhibitions of oxidative stress and inflammation. These finding definitely supports the ethnopharmacological use of LC as an anti-DN agent. [Display omitted]
AbstractList ETHNOPHARMACOLOGY RELEVANCERhizome of Ligusticum chuanxiong Hort. (Abbreviated as LC) is a frequently prescribed component in plenty of traditional Chinese medicine (TCM) formulas which are used to treat diabetic nephropathy (DN). The aims of the present study are to investigate the protective effect of the ethanol extract of LC rhizome (EEL) against DN in vivo, evaluate its potential mechanism, and find the evidence supporting its enthopharmacological use as an anti-DN agent. MATERIALS AND METHODSHepa 1c1c7 murine hepatoma cells, human breast carcinoma MDA-MB-231 cells, human renal glomerular endothelial cells (HRGEC), and RAW 264.7 murine macrophages were adopted to test the effects of EEL and its active constituents on inhibitions of oxidative stress and inflammation in vitro. A streptozotocin (STZ) -induced DN C57BL/6 mice model was established and used to investigate the preventive effect of EEL against DN in vivo. RESULTSEEL demonstrated potential inhibitory effects against oxidative stress and inflammation in vitro. Using a STZ-induced DN mice model, it has been found that EEL treatment significantly prevented STZ-induced increases of urine production, urinary albumin excretion (UAE) and urine albumin-to-creatinine ratio (UACR), and markedly attenuated STZ-induced renal damages (e.g. glomerulosclerosis and fibrosis). The predominant bioactive constituents, Z-ligustilide (LGT), ferulic acid (FA), and tetramethylpyrazine (TMP), were inhibitors of oxidative stress and inflammation through acting with Nrf2 and NF-κB pathways. CONCLUSIONSEEL attenuates structural and functional damages of kidney in STZ-induced DN model in vivo, which might be related to the functions of EEL on inhibitions of oxidative stress and inflammation. These finding definitely supports the ethnopharmacological use of LC as an anti-DN agent.
Rhizome of Ligusticum chuanxiong Hort. (Abbreviated as LC) is a frequently prescribed component in plenty of traditional Chinese medicine (TCM) formulas which are used to treat diabetic nephropathy (DN). The aims of the present study are to investigate the protective effect of the ethanol extract of LC rhizome (EEL) against DN in vivo, evaluate its potential mechanism, and find the evidence supporting its enthopharmacological use as an anti-DN agent. Hepa 1c1c7 murine hepatoma cells, human breast carcinoma MDA-MB-231 cells, human renal glomerular endothelial cells (HRGEC), and RAW 264.7 murine macrophages were adopted to test the effects of EEL and its active constituents on inhibitions of oxidative stress and inflammation in vitro. A streptozotocin (STZ) -induced DN C57BL/6 mice model was established and used to investigate the preventive effect of EEL against DN in vivo. EEL demonstrated potential inhibitory effects against oxidative stress and inflammation in vitro. Using a STZ-induced DN mice model, it has been found that EEL treatment significantly prevented STZ-induced increases of urine production, urinary albumin excretion (UAE) and urine albumin-to-creatinine ratio (UACR), and markedly attenuated STZ-induced renal damages (e.g. glomerulosclerosis and fibrosis). The predominant bioactive constituents, Z-ligustilide (LGT), ferulic acid (FA), and tetramethylpyrazine (TMP), were inhibitors of oxidative stress and inflammation through acting with Nrf2 and NF-κB pathways. EEL attenuates structural and functional damages of kidney in STZ-induced DN model in vivo, which might be related to the functions of EEL on inhibitions of oxidative stress and inflammation. These finding definitely supports the ethnopharmacological use of LC as an anti-DN agent.
Rhizome of Ligusticum chuanxiong Hort. (Abbreviated as LC) is a frequently prescribed component in plenty of traditional Chinese medicine (TCM) formulas which are used to treat diabetic nephropathy (DN). The aims of the present study are to investigate the protective effect of the ethanol extract of LC rhizome (EEL) against DN in vivo, evaluate its potential mechanism, and find the evidence supporting its enthopharmacological use as an anti-DN agent. Hepa 1c1c7 murine hepatoma cells, human breast carcinoma MDA-MB-231 cells, human renal glomerular endothelial cells (HRGEC), and RAW 264.7 murine macrophages were adopted to test the effects of EEL and its active constituents on inhibitions of oxidative stress and inflammation in vitro. A streptozotocin (STZ) -induced DN C57BL/6 mice model was established and used to investigate the preventive effect of EEL against DN in vivo. EEL demonstrated potential inhibitory effects against oxidative stress and inflammation in vitro. Using a STZ-induced DN mice model, it has been found that EEL treatment significantly prevented STZ-induced increases of urine production, urinary albumin excretion (UAE) and urine albumin-to-creatinine ratio (UACR), and markedly attenuated STZ-induced renal damages (e.g. glomerulosclerosis and fibrosis). The predominant bioactive constituents, Z-ligustilide (LGT), ferulic acid (FA), and tetramethylpyrazine (TMP), were inhibitors of oxidative stress and inflammation through acting with Nrf2 and NF-κB pathways. EEL attenuates structural and functional damages of kidney in STZ-induced DN model in vivo, which might be related to the functions of EEL on inhibitions of oxidative stress and inflammation. These finding definitely supports the ethnopharmacological use of LC as an anti-DN agent. [Display omitted]
Author Shen, Tao
Xiang, Lan
Gao, Hui
Wu, Xue-Yi
Li, Yan-Ru
Lou, Hong-Xiang
Ren, Dong-Mei
Yang, Wen-Jing
Wang, Xiao-Ling
Wang, Xiao-Ning
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  email: shentao@sdu.edu.cn
  organization: Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan, People's Republic of China
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Cites_doi 10.1089/ars.2012.5118
10.1139/apnm-2015-0002
10.2337/db11-0807
10.1016/j.niox.2014.05.014
10.1053/meta.2003.50096
10.3858/emm.2011.43.12.078
10.1016/j.taap.2017.11.025
10.1111/j.1755-5922.2010.00218.x
10.1021/acs.jmedchem.5b00393
10.1681/ASN.2007091048
10.1007/s11892-004-0055-z
10.1111/j.1440-1797.2007.00796.x
10.1101/cshperspect.a001651
10.1155/2012/465897
10.1155/2012/821936
10.2337/diacare.28.1.164
10.1016/j.phrs.2008.09.003
10.1016/j.jep.2018.04.017
10.1016/j.diabres.2017.04.010
10.1007/s001250051241
10.1016/j.redox.2017.09.004
10.1039/C6RA24274J
10.1089/ars.2016.6664
10.1038/nrendo.2010.212
10.1016/j.jep.2016.10.012
10.1007/s10616-015-9928-z
10.1016/j.freeradbiomed.2017.12.040
10.1056/NEJMoa1105351
10.1080/10715760500043132
10.1101/gad.225680.113
10.1155/2018/7616852
10.1016/j.cytogfr.2006.09.011
10.1016/j.phymed.2011.05.003
10.1016/j.diabres.2007.08.009
10.1007/s12263-007-0063-0
10.2337/db11-1072
10.1016/j.jep.2016.04.057
10.1007/s00592-003-0099-6
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Keywords ESRD
NO
COX-2
DI
DN
NF-κB
GFR
SF
Nrf2
STZ
iNOS
Diabetic nephropathy
NQO1
QR
IL
MQI
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8-oxo-dG
ARE
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LC
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Ligusticum chuanxiong
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References Zhang (bib38) 2013; 19
Sagoo, Gnudi (bib31) 2018; 116
Zuo, Song, Li, Zhang, Liang, Qi, Liu, Wang, Wang (bib42) 2012; 27
Sharma, Bhattacharya, Kalia, Tiwari (bib32) 2017; 128
Donkor, Chen, Ding, Qiu (bib7) 2016; 194
Lawrence (bib17) 2009; 1
Moriwaki, Yamamoto, Shibutani, Aoki, Tsutsumi, Takahashi, Okamura, Koga, Fukuchi, Hada (bib25) 2003; 52
Haghdoost, Czene, Naslund, Skog, Harms-Ringdahl (bib12) 2005; 39
Narasimhan, Chinnaiyan, Karundevi (bib26) 2015; 40
Lo Faro, Fox, Whatmore, Winyard, Whiteman (bib22) 2014; 41
Yang, Liang, Xu, Zhang, Xiao, Si (bib37) 2011; 18
Zheng, Whitman, Wu, Wondrak, Wong, Fang, Zhang (bib39) 2011; 60
Jaramillo, Zhang (bib13) 2013; 27
Sugimoto, Shikata, Wada, Horiuchi, Makino (bib34) 1999; 42
Li, Fu, Yang, Wang, Feng, Wang, Ren, Lou, Shen (bib19) 2018; 221
Jha, Banal, Chow, Cooper, Jandeleit-Dahm (bib14) 2016; 25
Li, Yang, Cheng, Chen (bib21) 2009; 3
Li, Zheng, Higgins, Morra, Mendis, Chien, Ojirna, Mierke, Dinkova-Kostova, Honda (bib18) 2015; 58
Ozbek (bib29) 2012; 2012
Zhou, Qu, Zhang, Liu, Yang, Chen, Li, Liu, Gao (bib40) 2016; 6
Elmarakby, Sullivan (bib8) 2012; 30
McGowan, Zhu, Sharma (bib24) 2004; 4
Ayhanci, Cengiz, Kutlu, Vejselova (bib2) 2016; 68
Li, Li, Sun, Li, Liu, Kong, Wang, Ren, Wang, Lou, Shen (bib20) 2018; 2018
Pergola, Raskin, Toto, Meyer, Huff, Grossman, Krauth, Ruiz, Audhya, Christ-Schmidt, Wittes, Warnock, Investigators (bib30) 2011; 365
Fujita, Sasaki, Doi, Okamoto, Matsuno, Furuta, Nishi, Nakao, Tsuno, Taniguchi, Nanjo (bib9) 2008; 79
Tesch, Allen (bib36) 2007; 12
Al-Hussaini, Kilarkaje (bib1) 2018; 339
Surh, Na (bib35) 2008; 2
Navarro, Mora-Fernandez (bib28) 2006; 17
Cui, Bai, Miao, Luo, Chen, Tan, Rane, Miao, Cai (bib5) 2012; 2012
Balasubashini, Rukkumani, Menon (bib3) 2003; 40
Lau, Villeneuve, Sun, Wong, Zhang (bib16) 2008; 58
Guillermina Miranda-Diaz, Pazarin-Villasenor, Gerardo Yanowsky-Escatell, Andrade-Sierra (bib11) 2016; 2016
Singh, Winocour, Farrington (bib33) 2011; 7
Choi, Kim, Naowaboot, Lee, Hyun, Cho, Lee, Lee, Yang, Chung (bib4) 2011; 43
Gross, de Azevedo, Silveiro, Canani, Caramori, Zelmanovitz (bib10) 2005; 28
Zhou, Li, Sun, Xu, Li, Li, Ren, Wang, Wen, Lou, Shen (bib41) 2018; 14
de Haan (bib6) 2011; 60
Jin, hong, Li, Li, Wang, Lv (bib15) 2013; 4
Navarro-Gonzalez, Mora-Fernandez (bib27) 2008; 19
Lucina Torres-Rodriguez, Garcia-Chavez, Berhow, de Mejia (bib23) 2016; 188
Jaramillo (10.1016/j.jep.2018.08.037_bib13) 2013; 27
Singh (10.1016/j.jep.2018.08.037_bib33) 2011; 7
Zhou (10.1016/j.jep.2018.08.037_bib41) 2018; 14
de Haan (10.1016/j.jep.2018.08.037_bib6) 2011; 60
Gross (10.1016/j.jep.2018.08.037_bib10) 2005; 28
Surh (10.1016/j.jep.2018.08.037_bib35) 2008; 2
Elmarakby (10.1016/j.jep.2018.08.037_bib8) 2012; 30
Ayhanci (10.1016/j.jep.2018.08.037_bib2) 2016; 68
Haghdoost (10.1016/j.jep.2018.08.037_bib12) 2005; 39
Lo Faro (10.1016/j.jep.2018.08.037_bib22) 2014; 41
McGowan (10.1016/j.jep.2018.08.037_bib24) 2004; 4
Navarro (10.1016/j.jep.2018.08.037_bib28) 2006; 17
Lawrence (10.1016/j.jep.2018.08.037_bib17) 2009; 1
Zhang (10.1016/j.jep.2018.08.037_bib38) 2013; 19
Sagoo (10.1016/j.jep.2018.08.037_bib31) 2018; 116
Zuo (10.1016/j.jep.2018.08.037_bib42) 2012; 27
Cui (10.1016/j.jep.2018.08.037_bib5) 2012; 2012
Pergola (10.1016/j.jep.2018.08.037_bib30) 2011; 365
Sugimoto (10.1016/j.jep.2018.08.037_bib34) 1999; 42
Li (10.1016/j.jep.2018.08.037_bib21) 2009; 3
Ozbek (10.1016/j.jep.2018.08.037_bib29) 2012; 2012
Al-Hussaini (10.1016/j.jep.2018.08.037_bib1) 2018; 339
Zheng (10.1016/j.jep.2018.08.037_bib39) 2011; 60
Fujita (10.1016/j.jep.2018.08.037_bib9) 2008; 79
Li (10.1016/j.jep.2018.08.037_bib19) 2018; 221
Narasimhan (10.1016/j.jep.2018.08.037_bib26) 2015; 40
Li (10.1016/j.jep.2018.08.037_bib20) 2018; 2018
Lucina Torres-Rodriguez (10.1016/j.jep.2018.08.037_bib23) 2016; 188
Tesch (10.1016/j.jep.2018.08.037_bib36) 2007; 12
Yang (10.1016/j.jep.2018.08.037_bib37) 2011; 18
Jin (10.1016/j.jep.2018.08.037_bib15) 2013; 4
Lau (10.1016/j.jep.2018.08.037_bib16) 2008; 58
Navarro-Gonzalez (10.1016/j.jep.2018.08.037_bib27) 2008; 19
Balasubashini (10.1016/j.jep.2018.08.037_bib3) 2003; 40
Guillermina Miranda-Diaz (10.1016/j.jep.2018.08.037_bib11) 2016; 2016
Jha (10.1016/j.jep.2018.08.037_bib14) 2016; 25
Choi (10.1016/j.jep.2018.08.037_bib4) 2011; 43
Zhou (10.1016/j.jep.2018.08.037_bib40) 2016; 6
Li (10.1016/j.jep.2018.08.037_bib18) 2015; 58
Donkor (10.1016/j.jep.2018.08.037_bib7) 2016; 194
Sharma (10.1016/j.jep.2018.08.037_bib32) 2017; 128
Moriwaki (10.1016/j.jep.2018.08.037_bib25) 2003; 52
References_xml – volume: 365
  start-page: 327
  year: 2011
  end-page: 336
  ident: bib30
  article-title: Bardoxolone methyl and kidney function in CKD with Type 2 diabetes
  publication-title: N. Engl. J. Med.
  contributor:
    fullname: Investigators
– volume: 25
  start-page: 657
  year: 2016
  end-page: 684
  ident: bib14
  article-title: Diabetes and kidney disease: role of oxidative stress
  publication-title: Antioxid. Redox Signal.
  contributor:
    fullname: Jandeleit-Dahm
– volume: 58
  start-page: 262
  year: 2008
  end-page: 270
  ident: bib16
  article-title: Dual roles of Nrf2 in cancer
  publication-title: Pharmacol. Res.
  contributor:
    fullname: Zhang
– volume: 52
  start-page: 605
  year: 2003
  end-page: 608
  ident: bib25
  article-title: Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy
  publication-title: Metab. Clin. Exp.
  contributor:
    fullname: Hada
– volume: 40
  start-page: 769
  year: 2015
  end-page: 781
  ident: bib26
  article-title: Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat
  publication-title: Appl. Physiol. Nutr. Metab.
  contributor:
    fullname: Karundevi
– volume: 43
  start-page: 676
  year: 2011
  end-page: 683
  ident: bib4
  article-title: Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes
  publication-title: Exp. Mol. Med.
  contributor:
    fullname: Chung
– volume: 4
  start-page: 44
  year: 2013
  end-page: 49
  ident: bib15
  article-title: Advancements in the chemical constituents and pharmacological effects of Chuanxiong
  publication-title: Zhong Yao Yu Lin Chuang
  contributor:
    fullname: Lv
– volume: 221
  start-page: 37
  year: 2018
  end-page: 47
  ident: bib19
  article-title: Investigation of constituents from
  publication-title: J. Ethnopharmacol.
  contributor:
    fullname: Shen
– volume: 42
  start-page: 878
  year: 1999
  end-page: 886
  ident: bib34
  article-title: Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the overexpression of tumour necrosis factor-alpha and inducible nitric oxide synthase in diabetic rat glomeruli
  publication-title: Diabetologia
  contributor:
    fullname: Makino
– volume: 2012
  start-page: 465897
  year: 2012
  ident: bib29
  article-title: Induction of oxidative stress in kidney
  publication-title: Int. J. Nephrol.
  contributor:
    fullname: Ozbek
– volume: 339
  start-page: 97
  year: 2018
  end-page: 109
  ident: bib1
  article-title: Trans-resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys
  publication-title: Toxicol. Appl. Pharmacol.
  contributor:
    fullname: Kilarkaje
– volume: 27
  start-page: 2179
  year: 2013
  end-page: 2191
  ident: bib13
  article-title: The emerging role of the Nrf2-Keap1 signaling pathway in cancer
  publication-title: Genes Dev.
  contributor:
    fullname: Zhang
– volume: 12
  start-page: 261
  year: 2007
  end-page: 266
  ident: bib36
  article-title: Rodent models of streptozotocin-induced diabetic nephropathy
  publication-title: Nephrology
  contributor:
    fullname: Allen
– volume: 17
  start-page: 441
  year: 2006
  end-page: 450
  ident: bib28
  article-title: The role of TNF-alpha in diabetic nephropathy: pathogenic and therapeutic implications
  publication-title: Cytokine Growth Factor Rev.
  contributor:
    fullname: Mora-Fernandez
– volume: 39
  start-page: 153
  year: 2005
  end-page: 162
  ident: bib12
  article-title: Extracellular 8-oxo-dG as a sensitive parameter for oxidative stress
  publication-title: Free Radic. Res.
  contributor:
    fullname: Harms-Ringdahl
– volume: 6
  start-page: 109132
  year: 2016
  end-page: 109142
  ident: bib40
  article-title: Antidiabetic effect of ligustilide-rich total lactones derived from Shunaoxin dropping pills on mice with type 2 diabetes induced by a high-fat diet and streptozotocin
  publication-title: RSC Adv.
  contributor:
    fullname: Gao
– volume: 116
  start-page: 50
  year: 2018
  end-page: 63
  ident: bib31
  article-title: Diabetic nephropathy: is there a role for oxidative stress?
  publication-title: Free Radic. Biol. Med.
  contributor:
    fullname: Gnudi
– volume: 1
  start-page: a001651
  year: 2009
  ident: bib17
  article-title: The Nuclear Factor NF-kappa B Pathway in Inflammation
  publication-title: Cold Spring Harb. Perspect. Biol.
  contributor:
    fullname: Lawrence
– volume: 194
  start-page: 530
  year: 2016
  end-page: 548
  ident: bib7
  article-title: Locally and traditionally used Ligusticum species - A review of their phytochemistry, pharmacology and pharmacokinetics
  publication-title: J. Ethnopharmacol.
  contributor:
    fullname: Qiu
– volume: 79
  start-page: 11
  year: 2008
  end-page: 17
  ident: bib9
  article-title: Ferulic acid prevents pathological and functional abnormalities of the kidney in Otsuka Long-Evans Tokushima Fatty diabetic rats
  publication-title: Diabetes Res. Clin. Pract.
  contributor:
    fullname: Nanjo
– volume: 128
  start-page: 91
  year: 2017
  end-page: 108
  ident: bib32
  article-title: Diabetic nephropathy: new insights into established therapeutic paradigms and novel molecular targets
  publication-title: Diabetes Res. Clin. Pract.
  contributor:
    fullname: Tiwari
– volume: 7
  start-page: 176
  year: 2011
  end-page: 184
  ident: bib33
  article-title: Oxidative stress in early diabetic nephropathy: fueling the fire
  publication-title: Nat. Rev. Endocrinol.
  contributor:
    fullname: Farrington
– volume: 2012
  start-page: 821936
  year: 2012
  ident: bib5
  article-title: Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation
  publication-title: Oxid. Med. Cell Longev.
  contributor:
    fullname: Cai
– volume: 19
  start-page: 433
  year: 2008
  end-page: 442
  ident: bib27
  article-title: The role of inflammatory cytokines in diabetic nephropathy
  publication-title: J. Am. Soc. Nephrol.
  contributor:
    fullname: Mora-Fernandez
– volume: 4
  start-page: 447
  year: 2004
  end-page: 454
  ident: bib24
  article-title: Transforming growth factor-beta: a clinical target for the treatment of diabetic nephropathy
  publication-title: Curr. Diab. Rep.
  contributor:
    fullname: Sharma
– volume: 60
  start-page: 3055
  year: 2011
  end-page: 3066
  ident: bib39
  article-title: Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
  publication-title: Diabetes
  contributor:
    fullname: Zhang
– volume: 30
  start-page: 49
  year: 2012
  end-page: 59
  ident: bib8
  article-title: Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy
  publication-title: Cardiovasc. Ther.
  contributor:
    fullname: Sullivan
– volume: 28
  start-page: 164
  year: 2005
  end-page: 176
  ident: bib10
  article-title: Diabetic nephropathy: diagnosis, prevention, and treatment
  publication-title: Diabetes Care
  contributor:
    fullname: Zelmanovitz
– volume: 58
  start-page: 4738
  year: 2015
  end-page: 4748
  ident: bib18
  article-title: New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase
  publication-title: J. Med. Chem.
  contributor:
    fullname: Honda
– volume: 2018
  start-page: 7616852
  year: 2018
  ident: bib20
  article-title: Ingredients from Litsea garrettii as potential preventive agents against oxidative insult and inflammatory response
  publication-title: Oxid. Med. Cell Longev.
  contributor:
    fullname: Shen
– volume: 40
  start-page: 118
  year: 2003
  end-page: 122
  ident: bib3
  article-title: Protective effects of ferulic acid on hyperlipidemic diabetic rats
  publication-title: Acta Diabetol.
  contributor:
    fullname: Menon
– volume: 19
  start-page: 517
  year: 2013
  end-page: 518
  ident: bib38
  article-title: Bardoxolone brings Nrf2-Based therapies to light
  publication-title: Antioxid. Redox Signal.
  contributor:
    fullname: Zhang
– volume: 60
  start-page: 2683
  year: 2011
  end-page: 2684
  ident: bib6
  article-title: Nrf2 activators as attractive therapeutics or diabetic nephropathy
  publication-title: Diabetes
  contributor:
    fullname: de Haan
– volume: 3
  start-page: 95
  year: 2009
  end-page: 96
  ident: bib21
  article-title: Therapeutical effects of Xuefu Zhuyu Tang-based prescription on diabetic nephropathy
  publication-title: Zhongguo Xiandai Yaowu Yingyong
  contributor:
    fullname: Chen
– volume: 188
  start-page: 266
  year: 2016
  end-page: 274
  ident: bib23
  article-title: Anti-inflammatory and anti-oxidant effect of Calea urticifolia lyophilized aqueous extract on lipopolysaccharide-stimulated RAW 264.7 macrophages
  publication-title: J. Ethnopharmacol.
  contributor:
    fullname: de Mejia
– volume: 18
  start-page: 1148
  year: 2011
  end-page: 1152
  ident: bib37
  article-title: Protective effect of tetramethylpyrazine isolated from
  publication-title: Phytomedicine
  contributor:
    fullname: Si
– volume: 14
  start-page: 154
  year: 2018
  end-page: 163
  ident: bib41
  article-title: Identification of novel Nrf2 activators from
  publication-title: Redox Biol.
  contributor:
    fullname: Shen
– volume: 41
  start-page: 38
  year: 2014
  end-page: 47
  ident: bib22
  article-title: Hydrogen sulfide and nitric oxide interactions in inflammation
  publication-title: Nitric Oxide
  contributor:
    fullname: Whiteman
– volume: 27
  start-page: 196
  year: 2012
  end-page: 198
  ident: bib42
  article-title: Exploration of the compatibility of Ligusticum Wallichii in the prevention and treatment of diabetic nephropathy
  publication-title: Zhong Yi Xue Bao
  contributor:
    fullname: Wang
– volume: 2016
  start-page: 7047238
  year: 2016
  ident: bib11
  article-title: Oxidative stress in diabetic nephropathy with early chronic kidney disease
  publication-title: J. Diabetes Res.
  contributor:
    fullname: Andrade-Sierra
– volume: 68
  start-page: 1763
  year: 2016
  end-page: 1770
  ident: bib2
  article-title: Protective effects of ellagic acid in D-galactosamine-induced kidney damage in rats
  publication-title: Cytotechnology
  contributor:
    fullname: Vejselova
– volume: 2
  start-page: 313
  year: 2008
  end-page: 317
  ident: bib35
  article-title: NF-kappa B and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals
  publication-title: Genes Nutr.
  contributor:
    fullname: Na
– volume: 19
  start-page: 517
  year: 2013
  ident: 10.1016/j.jep.2018.08.037_bib38
  article-title: Bardoxolone brings Nrf2-Based therapies to light
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2012.5118
  contributor:
    fullname: Zhang
– volume: 2016
  start-page: 7047238
  year: 2016
  ident: 10.1016/j.jep.2018.08.037_bib11
  article-title: Oxidative stress in diabetic nephropathy with early chronic kidney disease
  publication-title: J. Diabetes Res.
  contributor:
    fullname: Guillermina Miranda-Diaz
– volume: 27
  start-page: 196
  year: 2012
  ident: 10.1016/j.jep.2018.08.037_bib42
  article-title: Exploration of the compatibility of Ligusticum Wallichii in the prevention and treatment of diabetic nephropathy
  publication-title: Zhong Yi Xue Bao
  contributor:
    fullname: Zuo
– volume: 40
  start-page: 769
  year: 2015
  ident: 10.1016/j.jep.2018.08.037_bib26
  article-title: Ferulic acid exerts its antidiabetic effect by modulating insulin-signalling molecules in the liver of high-fat diet and fructose-induced type-2 diabetic adult male rat
  publication-title: Appl. Physiol. Nutr. Metab.
  doi: 10.1139/apnm-2015-0002
  contributor:
    fullname: Narasimhan
– volume: 60
  start-page: 3055
  year: 2011
  ident: 10.1016/j.jep.2018.08.037_bib39
  article-title: Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
  publication-title: Diabetes
  doi: 10.2337/db11-0807
  contributor:
    fullname: Zheng
– volume: 41
  start-page: 38
  year: 2014
  ident: 10.1016/j.jep.2018.08.037_bib22
  article-title: Hydrogen sulfide and nitric oxide interactions in inflammation
  publication-title: Nitric Oxide
  doi: 10.1016/j.niox.2014.05.014
  contributor:
    fullname: Lo Faro
– volume: 52
  start-page: 605
  year: 2003
  ident: 10.1016/j.jep.2018.08.037_bib25
  article-title: Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy
  publication-title: Metab. Clin. Exp.
  doi: 10.1053/meta.2003.50096
  contributor:
    fullname: Moriwaki
– volume: 4
  start-page: 44
  year: 2013
  ident: 10.1016/j.jep.2018.08.037_bib15
  article-title: Advancements in the chemical constituents and pharmacological effects of Chuanxiong
  publication-title: Zhong Yao Yu Lin Chuang
  contributor:
    fullname: Jin
– volume: 43
  start-page: 676
  year: 2011
  ident: 10.1016/j.jep.2018.08.037_bib4
  article-title: Effects of ferulic acid on diabetic nephropathy in a rat model of type 2 diabetes
  publication-title: Exp. Mol. Med.
  doi: 10.3858/emm.2011.43.12.078
  contributor:
    fullname: Choi
– volume: 339
  start-page: 97
  year: 2018
  ident: 10.1016/j.jep.2018.08.037_bib1
  article-title: Trans-resveratrol mitigates type 1 diabetes-induced oxidative DNA damage and accumulation of advanced glycation end products in glomeruli and tubules of rat kidneys
  publication-title: Toxicol. Appl. Pharmacol.
  doi: 10.1016/j.taap.2017.11.025
  contributor:
    fullname: Al-Hussaini
– volume: 30
  start-page: 49
  year: 2012
  ident: 10.1016/j.jep.2018.08.037_bib8
  article-title: Relationship between oxidative stress and inflammatory cytokines in diabetic nephropathy
  publication-title: Cardiovasc. Ther.
  doi: 10.1111/j.1755-5922.2010.00218.x
  contributor:
    fullname: Elmarakby
– volume: 58
  start-page: 4738
  year: 2015
  ident: 10.1016/j.jep.2018.08.037_bib18
  article-title: New monocyclic, bicyclic, and tricyclic ethynylcyanodienones as activators of the Keap1/Nrf2/ARE pathway and inhibitors of inducible nitric oxide synthase
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.5b00393
  contributor:
    fullname: Li
– volume: 19
  start-page: 433
  year: 2008
  ident: 10.1016/j.jep.2018.08.037_bib27
  article-title: The role of inflammatory cytokines in diabetic nephropathy
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2007091048
  contributor:
    fullname: Navarro-Gonzalez
– volume: 4
  start-page: 447
  year: 2004
  ident: 10.1016/j.jep.2018.08.037_bib24
  article-title: Transforming growth factor-beta: a clinical target for the treatment of diabetic nephropathy
  publication-title: Curr. Diab. Rep.
  doi: 10.1007/s11892-004-0055-z
  contributor:
    fullname: McGowan
– volume: 12
  start-page: 261
  year: 2007
  ident: 10.1016/j.jep.2018.08.037_bib36
  article-title: Rodent models of streptozotocin-induced diabetic nephropathy
  publication-title: Nephrology
  doi: 10.1111/j.1440-1797.2007.00796.x
  contributor:
    fullname: Tesch
– volume: 1
  start-page: a001651
  year: 2009
  ident: 10.1016/j.jep.2018.08.037_bib17
  article-title: The Nuclear Factor NF-kappa B Pathway in Inflammation
  publication-title: Cold Spring Harb. Perspect. Biol.
  doi: 10.1101/cshperspect.a001651
  contributor:
    fullname: Lawrence
– volume: 2012
  start-page: 465897
  year: 2012
  ident: 10.1016/j.jep.2018.08.037_bib29
  article-title: Induction of oxidative stress in kidney
  publication-title: Int. J. Nephrol.
  doi: 10.1155/2012/465897
  contributor:
    fullname: Ozbek
– volume: 2012
  start-page: 821936
  year: 2012
  ident: 10.1016/j.jep.2018.08.037_bib5
  article-title: Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation
  publication-title: Oxid. Med. Cell Longev.
  doi: 10.1155/2012/821936
  contributor:
    fullname: Cui
– volume: 28
  start-page: 164
  year: 2005
  ident: 10.1016/j.jep.2018.08.037_bib10
  article-title: Diabetic nephropathy: diagnosis, prevention, and treatment
  publication-title: Diabetes Care
  doi: 10.2337/diacare.28.1.164
  contributor:
    fullname: Gross
– volume: 58
  start-page: 262
  year: 2008
  ident: 10.1016/j.jep.2018.08.037_bib16
  article-title: Dual roles of Nrf2 in cancer
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2008.09.003
  contributor:
    fullname: Lau
– volume: 221
  start-page: 37
  year: 2018
  ident: 10.1016/j.jep.2018.08.037_bib19
  article-title: Investigation of constituents from Cinnamomum camphora (L.) J. Presl and evaluation of their anti-inflammatory properties in lipopolysaccharide-stimulated RAW 264.7 macrophages
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2018.04.017
  contributor:
    fullname: Li
– volume: 3
  start-page: 95
  year: 2009
  ident: 10.1016/j.jep.2018.08.037_bib21
  article-title: Therapeutical effects of Xuefu Zhuyu Tang-based prescription on diabetic nephropathy
  publication-title: Zhongguo Xiandai Yaowu Yingyong
  contributor:
    fullname: Li
– volume: 128
  start-page: 91
  year: 2017
  ident: 10.1016/j.jep.2018.08.037_bib32
  article-title: Diabetic nephropathy: new insights into established therapeutic paradigms and novel molecular targets
  publication-title: Diabetes Res. Clin. Pract.
  doi: 10.1016/j.diabres.2017.04.010
  contributor:
    fullname: Sharma
– volume: 42
  start-page: 878
  year: 1999
  ident: 10.1016/j.jep.2018.08.037_bib34
  article-title: Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the overexpression of tumour necrosis factor-alpha and inducible nitric oxide synthase in diabetic rat glomeruli
  publication-title: Diabetologia
  doi: 10.1007/s001250051241
  contributor:
    fullname: Sugimoto
– volume: 14
  start-page: 154
  year: 2018
  ident: 10.1016/j.jep.2018.08.037_bib41
  article-title: Identification of novel Nrf2 activators from Cinnamomum chartophyllum HW Li and their potential application of preventing oxidative insults in human lung epithelial cells
  publication-title: Redox Biol.
  doi: 10.1016/j.redox.2017.09.004
  contributor:
    fullname: Zhou
– volume: 6
  start-page: 109132
  year: 2016
  ident: 10.1016/j.jep.2018.08.037_bib40
  article-title: Antidiabetic effect of ligustilide-rich total lactones derived from Shunaoxin dropping pills on mice with type 2 diabetes induced by a high-fat diet and streptozotocin
  publication-title: RSC Adv.
  doi: 10.1039/C6RA24274J
  contributor:
    fullname: Zhou
– volume: 25
  start-page: 657
  year: 2016
  ident: 10.1016/j.jep.2018.08.037_bib14
  article-title: Diabetes and kidney disease: role of oxidative stress
  publication-title: Antioxid. Redox Signal.
  doi: 10.1089/ars.2016.6664
  contributor:
    fullname: Jha
– volume: 7
  start-page: 176
  year: 2011
  ident: 10.1016/j.jep.2018.08.037_bib33
  article-title: Oxidative stress in early diabetic nephropathy: fueling the fire
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2010.212
  contributor:
    fullname: Singh
– volume: 194
  start-page: 530
  year: 2016
  ident: 10.1016/j.jep.2018.08.037_bib7
  article-title: Locally and traditionally used Ligusticum species - A review of their phytochemistry, pharmacology and pharmacokinetics
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2016.10.012
  contributor:
    fullname: Donkor
– volume: 68
  start-page: 1763
  year: 2016
  ident: 10.1016/j.jep.2018.08.037_bib2
  article-title: Protective effects of ellagic acid in D-galactosamine-induced kidney damage in rats
  publication-title: Cytotechnology
  doi: 10.1007/s10616-015-9928-z
  contributor:
    fullname: Ayhanci
– volume: 116
  start-page: 50
  year: 2018
  ident: 10.1016/j.jep.2018.08.037_bib31
  article-title: Diabetic nephropathy: is there a role for oxidative stress?
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2017.12.040
  contributor:
    fullname: Sagoo
– volume: 365
  start-page: 327
  year: 2011
  ident: 10.1016/j.jep.2018.08.037_bib30
  article-title: Bardoxolone methyl and kidney function in CKD with Type 2 diabetes
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa1105351
  contributor:
    fullname: Pergola
– volume: 39
  start-page: 153
  year: 2005
  ident: 10.1016/j.jep.2018.08.037_bib12
  article-title: Extracellular 8-oxo-dG as a sensitive parameter for oxidative stress in vivo and in vitro
  publication-title: Free Radic. Res.
  doi: 10.1080/10715760500043132
  contributor:
    fullname: Haghdoost
– volume: 27
  start-page: 2179
  year: 2013
  ident: 10.1016/j.jep.2018.08.037_bib13
  article-title: The emerging role of the Nrf2-Keap1 signaling pathway in cancer
  publication-title: Genes Dev.
  doi: 10.1101/gad.225680.113
  contributor:
    fullname: Jaramillo
– volume: 2018
  start-page: 7616852
  year: 2018
  ident: 10.1016/j.jep.2018.08.037_bib20
  article-title: Ingredients from Litsea garrettii as potential preventive agents against oxidative insult and inflammatory response
  publication-title: Oxid. Med. Cell Longev.
  doi: 10.1155/2018/7616852
  contributor:
    fullname: Li
– volume: 17
  start-page: 441
  year: 2006
  ident: 10.1016/j.jep.2018.08.037_bib28
  article-title: The role of TNF-alpha in diabetic nephropathy: pathogenic and therapeutic implications
  publication-title: Cytokine Growth Factor Rev.
  doi: 10.1016/j.cytogfr.2006.09.011
  contributor:
    fullname: Navarro
– volume: 18
  start-page: 1148
  year: 2011
  ident: 10.1016/j.jep.2018.08.037_bib37
  article-title: Protective effect of tetramethylpyrazine isolated from Ligusticum chuanxiong on nephropathy in rats with streptozotocin-induced diabetes
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2011.05.003
  contributor:
    fullname: Yang
– volume: 79
  start-page: 11
  year: 2008
  ident: 10.1016/j.jep.2018.08.037_bib9
  article-title: Ferulic acid prevents pathological and functional abnormalities of the kidney in Otsuka Long-Evans Tokushima Fatty diabetic rats
  publication-title: Diabetes Res. Clin. Pract.
  doi: 10.1016/j.diabres.2007.08.009
  contributor:
    fullname: Fujita
– volume: 2
  start-page: 313
  year: 2008
  ident: 10.1016/j.jep.2018.08.037_bib35
  article-title: NF-kappa B and Nrf2 as prime molecular targets for chemoprevention and cytoprotection with anti-inflammatory and antioxidant phytochemicals
  publication-title: Genes Nutr.
  doi: 10.1007/s12263-007-0063-0
  contributor:
    fullname: Surh
– volume: 60
  start-page: 2683
  year: 2011
  ident: 10.1016/j.jep.2018.08.037_bib6
  article-title: Nrf2 activators as attractive therapeutics or diabetic nephropathy
  publication-title: Diabetes
  doi: 10.2337/db11-1072
  contributor:
    fullname: de Haan
– volume: 188
  start-page: 266
  year: 2016
  ident: 10.1016/j.jep.2018.08.037_bib23
  article-title: Anti-inflammatory and anti-oxidant effect of Calea urticifolia lyophilized aqueous extract on lipopolysaccharide-stimulated RAW 264.7 macrophages
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2016.04.057
  contributor:
    fullname: Lucina Torres-Rodriguez
– volume: 40
  start-page: 118
  year: 2003
  ident: 10.1016/j.jep.2018.08.037_bib3
  article-title: Protective effects of ferulic acid on hyperlipidemic diabetic rats
  publication-title: Acta Diabetol.
  doi: 10.1007/s00592-003-0099-6
  contributor:
    fullname: Balasubashini
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Snippet Rhizome of Ligusticum chuanxiong Hort. (Abbreviated as LC) is a frequently prescribed component in plenty of traditional Chinese medicine (TCM) formulas which...
ETHNOPHARMACOLOGY RELEVANCERhizome of Ligusticum chuanxiong Hort. (Abbreviated as LC) is a frequently prescribed component in plenty of traditional Chinese...
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SubjectTerms Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Antioxidants - pharmacology
Antioxidants - therapeutic use
Cell Line
Cell Survival - drug effects
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - pathology
Diabetic Nephropathies - drug therapy
Diabetic Nephropathies - metabolism
Diabetic Nephropathies - pathology
Diabetic nephropathy
Humans
Ligusticum
Ligusticum chuanxiong
Male
Mice
Mice, Inbred C57BL
NF-E2-Related Factor 2 - metabolism
NF-kappa B - metabolism
NF-κB
Nrf2
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rhizome
Title Protective effect of the ethanol extract from Ligusticum chuanxiong rhizome against streptozotocin–induced diabetic nephropathy in mice
URI https://dx.doi.org/10.1016/j.jep.2018.08.037
https://www.ncbi.nlm.nih.gov/pubmed/30176347
https://search.proquest.com/docview/2099432826
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