Resveratrol inhibits matrix metalloproteinase-1 and -3 expression by suppressing of p300/NFκB acetylation in TNF-α-treated human dermal fibroblasts

• Published in: Chemico-biological interactions Vol. 337; p. 109395
• Main Authors: Lu, Yi-En, Chen, Ying-Jung
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.03.2021
• Subjects: Acetylation - drug effects; Binding Sites; Cell Survival - drug effects; Dermal fibroblasts; Down-Regulation - drug effects; E1A-Associated p300 Protein - antagonists & inhibitors; E1A-Associated p300 Protein - genetics; E1A-Associated p300 Protein - metabolism; Fibroblasts - cytology; Fibroblasts - drug effects; Fibroblasts - metabolism; Humans; Matrix metalloproteinase; Matrix Metalloproteinase 1 - genetics; Matrix Metalloproteinase 1 - metabolism; Matrix Metalloproteinase 3 - genetics; Matrix Metalloproteinase 3 - metabolism; NF-kappa B - metabolism; Nitriles - pharmacology; p300; Phosphorylation - drug effects; Promoter Regions, Genetic; Resveratrol; Resveratrol - pharmacology; RNA Interference; RNA, Small Interfering - metabolism; Sulfones - pharmacology; Transcription Factor RelA - metabolism; Tumor Necrosis Factor-alpha - pharmacology; Up-Regulation - drug effects; Wound healing; p300; Dermal fibroblasts; Wound healing; Matrix metalloproteinase; Resveratrol

The aim of this study was to explore the signaling pathways associated with the effects of tumor necrosis factor alpha (TNF-α) on matrix metalloproteinase-1 (MMP-1) and MMP-3 expression in the human dermal fibroblast cell line CCD-966SK. TNF-α upregulated MMP-1 and MMP-3 mRNA and protein expression,...