Persistent Extracellular Signal-Regulated Kinase Activation by the Histamine H4 Receptor in Spinal Neurons Underlies Chronic Itch

• Published in: Journal of investigative dermatology Vol. 138; no. 8; pp. 1843 - 1850
• Main Authors: Huang, Kun, Hu, Dan-Dan, Bai, Dong, Wu, Ze-Yang, Chen, Yi-Yang, Zhang, Yi-Jun, Lv, Xin, Wang, Qing-Xiu, Zhang, Ling
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2018
• Subjects: PBS; pERK; ERK

Transient extracellular signal-regulated kinase (ERK) activation in the spinal cord triggers histamine-induced acute itch. However, whether persistent ERK activation plays an important role in chronic itch development remains unclear. This study investigated the role of spinal ERK activation in chro...