First example of a heterobimetallic ‘Pd–Sn’ catalyst for direct activation of alcohol: efficient allylation, benzylation and propargylation of arenes, heteroarenes, active methylenes and allyl-Si nucleophiles

• Published in: Organic & biomolecular chemistry Vol. 10; no. 23; pp. 4537 - 4542
• Main Authors: Das, Debjit, Pratihar, Sanjay, Roy, Ujjal Kanti, Mal, Dipakranjan, Roy, Sujit
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 21.06.2012
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; SUBSTITUTION; INSERTION; SECONDARY BENZYLATION; HETEROGENEOUS ADDITION; COMPLEXES; ALLENYLATION; AROMATICS; FRIEDEL-CRAFTS ALKYLATION; DERIVATIVES; INDOLES

Arenes, heteroarenes, 1,3-dicarbonyls and organosilicon nucleophiles undergo highly efficient alkylation with allylic, propargylic and benzylic alcohols in the presence of a new 'Pd-Sn' bimetallic catalyst in nitromethane; water being the sole byproduct. The plausible mechanism of alkylati...