Methylmalonic acid in aging and disease

• Published in: Trends in endocrinology and metabolism Vol. 35; no. 3; pp. 188 - 200
• Main Authors: Tejero, Joanne, Lazure, Felicia, Gomes, Ana P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.03.2024
• Subjects: aging; disease; metabolism; methylmalonic acid; methylmalonic acid; metabolism; disease; aging

Methylmalonic acid (MMA) is a byproduct of propionate metabolism linked to vitamin B12 deficiency.MMA alters cellular metabolism through direct regulation of metabolic enzymes.MMA activates succinate receptor 1 and drives inflammation.MMA acts as a signaling molecule through methylmalonylation of pr...