Evidence for non-linear metabolism at low benzene exposures? A reanalysis of data

• Published in: Chemico-biological interactions Vol. 278; pp. 256 - 268
• Main Authors: McNally, K., Sams, C., Loizou, G.D., Jones, K.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 25.12.2017
• Subjects: Benzene; Linearity; Low dose; Metabolites; Specificity; Urine; Urine; Specificity; Metabolites; Benzene; Low dose; Linearity

The presence of a high-affinity metabolic pathway for low level benzene exposures of less than one part per million (ppm) has been proposed although a pathway has not been identified. The variation of metabolite molar fractions with increasing air benzene concentrations was suggested as evidence of...