Impact of age and gender on glioblastoma onset, progression, and management
Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its frequency in pediatric patients is 10–15%. For this reason, age is considered one of the major risk factors for the development of GBM, as it correlates with cellular aging phenomena involving glial cells and fa...
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| Published in | Mechanisms of ageing and development Vol. 211; p. 111801 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier B.V
01.04.2023
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0047-6374 1872-6216 1872-6216 |
| DOI | 10.1016/j.mad.2023.111801 |
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| Abstract | Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its frequency in pediatric patients is 10–15%. For this reason, age is considered one of the major risk factors for the development of GBM, as it correlates with cellular aging phenomena involving glial cells and favoring the process of tumor transformation. Gender differences have been also identified, as the incidence of GBM is higher in males than in females, coupled with a worse outcome. In this review, we analyze age- and gender- dependent differences in GBM onset, mutational landscape, clinical manifestations, and survival, according to the literature of the last 20 years, focusing on the major risk factors involved in tumor development and on the mutations and gene alterations most frequently found in adult vs young patients and in males vs females. We then highlight the impact of age and gender on clinical manifestations and tumor localization and their involvement in the time of diagnosis and in determining the tumor prognostic value.
•Glioblastoma is the most common primary malignant brain tumor in adults.•The incidence of glioblastoma is higher in males than in females•Chemotherapy is more effective in adult compared to pediatric patients |
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| AbstractList | Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its frequency in pediatric patients is 10-15%. For this reason, age is considered one of the major risk factors for the development of GBM, as it correlates with cellular aging phenomena involving glial cells and favoring the process of tumor transformation. Gender differences have been also identified, as the incidence of GBM is higher in males than in females, coupled with a worse outcome. In this review, we analyze age- and gender- dependent differences in GBM onset, mutational landscape, clinical manifestations, and survival, according to the literature of the last 20 years, focusing on the major risk factors involved in tumor development and on the mutations and gene alterations most frequently found in adult vs young patients and in males vs females. We then highlight the impact of age and gender on clinical manifestations and tumor localization and their involvement in the time of diagnosis and in determining the tumor prognostic value.Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its frequency in pediatric patients is 10-15%. For this reason, age is considered one of the major risk factors for the development of GBM, as it correlates with cellular aging phenomena involving glial cells and favoring the process of tumor transformation. Gender differences have been also identified, as the incidence of GBM is higher in males than in females, coupled with a worse outcome. In this review, we analyze age- and gender- dependent differences in GBM onset, mutational landscape, clinical manifestations, and survival, according to the literature of the last 20 years, focusing on the major risk factors involved in tumor development and on the mutations and gene alterations most frequently found in adult vs young patients and in males vs females. We then highlight the impact of age and gender on clinical manifestations and tumor localization and their involvement in the time of diagnosis and in determining the tumor prognostic value. Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its frequency in pediatric patients is 10-15%. For this reason, age is considered one of the major risk factors for the development of GBM, as it correlates with cellular aging phenomena involving glial cells and favoring the process of tumor transformation. Gender differences have been also identified, as the incidence of GBM is higher in males than in females, coupled with a worse outcome. In this review, we analyze age- and gender- dependent differences in GBM onset, mutational landscape, clinical manifestations, and survival, according to the literature of the last 20 years, focusing on the major risk factors involved in tumor development and on the mutations and gene alterations most frequently found in adult vs young patients and in males vs females. We then highlight the impact of age and gender on clinical manifestations and tumor localization and their involvement in the time of diagnosis and in determining the tumor prognostic value. Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its frequency in pediatric patients is 10–15%. For this reason, age is considered one of the major risk factors for the development of GBM, as it correlates with cellular aging phenomena involving glial cells and favoring the process of tumor transformation. Gender differences have been also identified, as the incidence of GBM is higher in males than in females, coupled with a worse outcome. In this review, we analyze age- and gender- dependent differences in GBM onset, mutational landscape, clinical manifestations, and survival, according to the literature of the last 20 years, focusing on the major risk factors involved in tumor development and on the mutations and gene alterations most frequently found in adult vs young patients and in males vs females. We then highlight the impact of age and gender on clinical manifestations and tumor localization and their involvement in the time of diagnosis and in determining the tumor prognostic value. •Glioblastoma is the most common primary malignant brain tumor in adults.•The incidence of glioblastoma is higher in males than in females•Chemotherapy is more effective in adult compared to pediatric patients |
| ArticleNumber | 111801 |
| Author | Fuda, Serena Onorato, Angelo Santi, Samuele Salvati, Maurizio Dolci, Susanna Guida, Eugenia Balistreri, Carmela Rita Colopi, Ambra Cesarini, Valeriana |
| Author_xml | – sequence: 1 givenname: Ambra surname: Colopi fullname: Colopi, Ambra organization: Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy – sequence: 2 givenname: Serena surname: Fuda fullname: Fuda, Serena organization: Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy – sequence: 3 givenname: Samuele surname: Santi fullname: Santi, Samuele organization: Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy – sequence: 4 givenname: Angelo surname: Onorato fullname: Onorato, Angelo organization: Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy – sequence: 5 givenname: Valeriana surname: Cesarini fullname: Cesarini, Valeriana organization: Department of Biomedicine, Institute of Translational Pharmacology-CNR, Rome, Italy – sequence: 6 givenname: Maurizio surname: Salvati fullname: Salvati, Maurizio organization: Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy – sequence: 7 givenname: Carmela Rita surname: Balistreri fullname: Balistreri, Carmela Rita organization: Cellular and Molecular Laboratory, Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, Corso Tukory 211, 90134 Palermo, Italy – sequence: 8 givenname: Susanna orcidid: 0000-0002-6864-3673 surname: Dolci fullname: Dolci, Susanna email: dolci@uniroma2.it organization: Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy – sequence: 9 givenname: Eugenia orcidid: 0000-0002-1690-3277 surname: Guida fullname: Guida, Eugenia email: eugenia.guida@uniroma2.it organization: Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36996926$$D View this record in MEDLINE/PubMed |
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| Keywords | Gender Age Glioblastoma High grade glioma |
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| Snippet | Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its frequency in pediatric patients is 10–15%. For this reason, age is... Glioblastoma (GBM) is the most common primary malignant brain tumor in adults, while its frequency in pediatric patients is 10-15%. For this reason, age is... |
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| SubjectTerms | Age Brain Neoplasms - epidemiology Brain Neoplasms - genetics Brain Neoplasms - therapy Female Gender Glioblastoma Glioblastoma - genetics Glioblastoma - therapy High grade glioma Humans Male Mutation Prognosis Risk Factors |
| Title | Impact of age and gender on glioblastoma onset, progression, and management |
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