Three-dimensional structure analysis of melanocytes and keratinocytes in senile lentigo

• Published in: Microscopy Vol. 70; no. 2; p. 224
• Main Authors: Mizutani, Yuki, Yamashita, Mika, Hashimoto, Rie, Atsugi, Toru, Ryu, Akemi, Hayashi, Akinobu, Rikimaru-Nishi, Yukiko, Ohta, Keisuke
• Format: Journal Article
• Language: English
• Published: England 01.04.2021
• Subjects: FIB-SEM; cell–cell interaction; melanocyte; melanosome; senile lentigo; three-dimensional structure

Senile lentigo or age spots are hyperpigmented macules of skin that commonly develop following long-term exposure to ultraviolet radiation. This condition is caused by accumulation of large numbers of melanosomes (melanin granules) produced by melanocytes within neighboring keratinocytes. However, t...