Analgesic targets identified in mouse sensory neuron somata and terminal pain translatomes

• Published in: Cell reports (Cambridge) Vol. 43; no. 8; p. 114614
• Main Authors: Bangash, M. Ali, Cubuk, Cankut, Iseppon, Federico, Haroun, Rayan, Garcia, Chloe, Luiz, Ana P., Arcangeletti, Manuel, Gossage, Samuel J., Santana-Varela, Sonia, Cox, James J., Lewis, Myles J., Wood, John N., Zhao, Jing
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 27.08.2024; Elsevier
• Subjects: Animals; CP: Neuroscience; Female; Ganglia, Spinal - metabolism; Glutamate Decarboxylase - genetics; Glutamate Decarboxylase - metabolism; Male; Mice; Mice, Inbred C57BL; NAV1.7 Voltage-Gated Sodium Channel - genetics; NAV1.7 Voltage-Gated Sodium Channel - metabolism; Pain - metabolism; Polyribosomes - metabolism; Protein Biosynthesis; Sensory Receptor Cells - metabolism; CP: Neuroscience

The relationship between transcription and protein expression is complex. We identified polysome-associated RNA transcripts in the somata and central terminals of mouse sensory neurons in control, painful (plus nerve growth factor), and pain-free conditions (Nav1.7-null mice). The majority (98%) of...