MicroRNA-132 regulates total protein of Nav1.1 and Nav1.2 in the hippocampus and cortex of rat with chronic cerebral hypoperfusion

• Published in: Behavioural brain research Vol. 366; pp. 118 - 125
• Main Authors: Hu, Xue-Ling, Wang, Xiao-Xue, Zhu, Yan-Meng, Xuan, Li-Na, Peng, Li-Wei, Liu, Yun-Qi, Yang, Hua, Yang, Chao, Jiao, Lei, Hang, Peng-Zhou, Sun, Li-Hua
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 02.07.2019
• Subjects: Animals; Brain Ischemia - metabolism; Brain Ischemia - pathology; Cerebral Cortex - blood supply; Cerebral Cortex - metabolism; Cerebral Cortex - pathology; Cerebrovascular Circulation - physiology; Chronic cerebral hypoperfusion; Cognitive Dysfunction - metabolism; Cognitive Dysfunction - pathology; Dementia - metabolism; Dementia - pathology; Disease Models, Animal; HEK293 Cells; Hippocampus - blood supply; Hippocampus - metabolism; Hippocampus - pathology; Humans; Male; MicroRNAs - genetics; MicroRNAs - metabolism; miR-132; Nav1.1; NAV1.1 Voltage-Gated Sodium Channel - genetics; NAV1.1 Voltage-Gated Sodium Channel - metabolism; Nav1.2; NAV1.2 Voltage-Gated Sodium Channel - genetics; NAV1.2 Voltage-Gated Sodium Channel - metabolism; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurons - metabolism; Neurons - pathology; Rats; Rats, Sprague-Dawley; Temporal Lobe - pathology; AChE; HEK293T; MWM; AD; AMO; qRT-PCR; PTEN; CCH; CNS; PP2A; 2VO; VD; BACE1; Nav1.2; LAMP-2; miR-132; Nav1.1; TRIM2; GA; Chronic cerebral hypoperfusion; NOS1; FOXO3a; ODNs

•miR-132 was decreased in hippocampus and cortex of rats after chronic cerebral hypoperfusion (CCH).•miR-132 improved dementia susceptibility induced by 2VO.•miR-132 prevents CCH-induced learning and memory impairments by down-regulating the expression of Nav1.1 and Nav1.2.•Voltage-gated sodium chan...