Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family

• Published in: Developmental cell Vol. 56; no. 6; pp. 726 - 746
• Main Authors: Katsuno, Yoko, Derynck, Rik
• Format: Journal Article
• Language: English
• Published: United States 22.03.2021
• Subjects: wound healing; activins; stem cell properties; cell migration; cancer; fibrosis; cell invasion; bone morphogenetic proteins

Epithelial cells repress epithelial characteristics and elaborate mesenchymal characteristics to migrate to other locations and acquire new properties. Epithelial plasticity responses are directed through cooperation of signaling pathways, with TGF-β and TGF-β-related proteins playing prominent inst...