Combined use of serum MCP-1/IL-10 ratio and uterine artery Doppler index significantly improves the prediction of preeclampsia

• Published in: Clinica chimica acta Vol. 473; pp. 228 - 236
• Main Authors: Cui, Shihong, Gao, Yanan, Zhang, Linlin, Wang, Yuan, Zhang, Lindong, Liu, Pingping, Liu, Ling, Chen, Juan
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2017
• Subjects: Adult; Anti-inflammatory; Chemokine CCL2 - blood; Female; Humans; IL-10; Interleukin-10 - blood; MCP-1; Pre-Eclampsia - blood; Pre-Eclampsia - diagnosis; Pre-Eclampsia - diagnostic imaging; Preeclampsia; Pregnancy; Pro-inflammatory; Prognosis; Ultrasonography, Doppler; Uterine Artery - diagnostic imaging; Uterine artery Doppler; Uterine artery Doppler; MCP-1; Pro-inflammatory; Anti-inflammatory; Preeclampsia; IL-10

Background: Monocyte chemotactic protein-1 (MCP-1, or CCL2) is a member of the chemokine subfamily involved in recruitment of monocytes in inflammatory tissues. IL-10 is a key regulator for maintaining the balance of anti-inflammatory and pro-inflammatory milieu at the feto-maternal interface. Doppl...