Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution

• Published in: Chemical communications (Cambridge, England) Vol. 51; no. 2; pp. 391 - 394
• Main Authors: Nishihara, Ryo, Suzuki, Hideyuki, Hoshino, Emi, Suganuma, Sakura, Sato, Moritoshi, Saitoh, Tsuyoshi, Nishiyama, Shigeru, Iwasawa, Naoko, Citterio, Daniel, Suzuki, Koji
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.01.2015
• Subjects: Animals; Bioluminescence; chemical compounds; chemical reactions; Chemistry; Chemistry, Multidisciplinary; Derivatives; Emission; Imidazoles - chemistry; Imidazoles - metabolism; luciferase; Luciferases, Renilla - metabolism; Luminescent Agents - chemistry; Luminescent Agents - metabolism; Luminescent Measurements; Optical properties; Physical Sciences; Pyrazines - chemistry; Pyrazines - metabolism; Renilla; Renilla - enzymology; Science & Technology; Substrate Specificity; LIVING SUBJECTS; GREEN FLUORESCENT PROTEIN; VARIANTS; RENILLA-RENIFORMIS; CHEMILUMINESCENCE; SUBSTRATE; IN-VIVO; LUCIFERIN ANALOGS; ENERGY-TRANSFER; OPLOPHORUS

Three novel coelenterazine (CTZ) derivatives with extension at the C-6 position of the imidazopyrazinone structure show significant bioluminescence emission with known renilla luciferase variants, indicating a promising method to develop CTZ derivatives with superior optical properties compared to h...