Bioluminescent coelenterazine derivatives with imidazopyrazinone C-6 extended substitution

Three novel coelenterazine (CTZ) derivatives with extension at the C-6 position of the imidazopyrazinone structure show significant bioluminescence emission with known renilla luciferase variants, indicating a promising method to develop CTZ derivatives with superior optical properties compared to h...

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Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 51; no. 2; pp. 391 - 394
Main Authors Nishihara, Ryo, Suzuki, Hideyuki, Hoshino, Emi, Suganuma, Sakura, Sato, Moritoshi, Saitoh, Tsuyoshi, Nishiyama, Shigeru, Iwasawa, Naoko, Citterio, Daniel, Suzuki, Koji
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 01.01.2015
Subjects
Animals
Bioluminescence
chemical compounds
chemical reactions
Chemistry
Chemistry, Multidisciplinary
Derivatives
Emission
Imidazoles - chemistry
Imidazoles - metabolism
luciferase
Luciferases, Renilla - metabolism
Luminescent Agents - chemistry
Luminescent Agents - metabolism
Luminescent Measurements
Optical properties
Physical Sciences
Pyrazines - chemistry
Pyrazines - metabolism
Renilla
Renilla - enzymology
Science & Technology
Substrate Specificity
LIVING SUBJECTS
GREEN FLUORESCENT PROTEIN
VARIANTS
RENILLA-RENIFORMIS
CHEMILUMINESCENCE
SUBSTRATE
IN-VIVO
LUCIFERIN ANALOGS
ENERGY-TRANSFER
OPLOPHORUS
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Summary:Three novel coelenterazine (CTZ) derivatives with extension at the C-6 position of the imidazopyrazinone structure show significant bioluminescence emission with known renilla luciferase variants, indicating a promising method to develop CTZ derivatives with superior optical properties compared to hitherto reported compounds.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/C4CC06886F