16α-OHE1 alleviates hypoxia-induced inflammation and myocardial damage via the activation of β2-Adrenergic receptor

• Published in: Molecular and cellular endocrinology Vol. 587; p. 112200
• Main Authors: Zhou, Yequan, Yin, Zeyuan, Cui, Junchao, Wang, Cheng, Fu, Tong, Adu-Amankwaah, Joseph, Fu, Lu, Zhou, Xueyan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.06.2024
• Subjects: 16α-OHE1; Estrogen metabolites; Hypoxia; Myocardial injury; β2-adrenergic receptor; Hypoxia; 16α-OHE1; β2-adrenergic receptor; Myocardial injury; Estrogen metabolites; β-adrenergic receptor

Myocardial injuries resulting from hypoxia are a significant concern, and this study aimed to explore potential protective strategies against such damage. Specifically, we sought to investigate the cardioprotective effects of 16α-hydroxyestrone (16α-OHE1). Male Sprague‒Dawley (SD) rats were subjecte...