Postnatal exposure to poly (I:C) impairs learning and memory through changes in synaptic plasticity gene expression in developing rat brain

• Published in: Neurobiology of learning and memory Vol. 155; pp. 379 - 389
• Main Authors: Baghel, Meghraj Singh, Singh, Brijendra, Dhuriya, Yogesh Kumar, Shukla, Rajendra Kumar, Patro, Nisha, Khanna, Vinay Kumar, Patro, Ishan Kumar, Thakur, Mahendra Kumar
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2018
• Subjects: Developmental neurological disorder; Memory; Poly (I:C); Synaptic proteins; TNF-α; Poly (I:C); TNF-α; Developmental neurological disorder; Memory; Synaptic proteins

•Early life poly (I:C) exposure impaired spatial and fear conditioning memory in 3, 6 and 12 weeks rats.•It elevated TNF-α expression in CA1 and DG at early phase of infection and persisted upto 12 weeks.•It decreased 3H-QNB binding to cholinergic receptor in frontal cortex and hippocampus of 3 and...