Cohesin mediates DNA loop extrusion and sister chromatid cohesion by distinct mechanisms

• Published in: Molecular cell Vol. 83; no. 17; pp. 3049 - 3063.e6
• Main Authors: Nagasaka, Kota, Davidson, Iain F., Stocsits, Roman R., Tang, Wen, Wutz, Gordana, Batty, Paul, Panarotto, Melanie, Litos, Gabriele, Schleiffer, Alexander, Gerlich, Daniel W., Peters, Jan-Michael
• Format: Journal Article
• Language: English
• Published: United States 07.09.2023
• Subjects: Binding Sites; Cell Cycle Proteins - genetics; Chromatids - genetics; Chromosomal Proteins, Non-Histone - genetics; Cohesins; Humans; chromatin architectures; cohesin; CTCF; TADs; cohesion; DNA loop extrusion

Cohesin connects CTCF-binding sites and other genomic loci in cis to form chromatin loops and replicated DNA molecules in trans to mediate sister chromatid cohesion. Whether cohesin uses distinct or related mechanisms to perform these functions is unknown. Here, we describe a cohesin hinge mutant th...