Pharmacogenetics of the anti-HCV drug sofosbuvir: a preliminary study

• Published in: Journal of antimicrobial chemotherapy Vol. 73; no. 6; pp. 1659 - 1664
• Main Authors: Cusato, Jessica, De Nicolò, Amedeo, Boglione, Lucio, Favata, Fabio, Ariaudo, Alessandra, Mornese Pinna, Simone, Carcieri, Chiara, Guido, Federica, Avataneo, Valeria, Cariti, Giuseppe, Di Perri, Giovanni, D’Avolio, Antonio
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.06.2018

Abstract Background Sofosbuvir is a potent nucleotide HCV NS5B polymerase inhibitor that is also a P-glycoprotein (encoded by the ABCB1 gene) and breast cancer resistance protein (encoded by the ABCG2 gene) substrate. Concerning previous anti-HCV therapies, pharmacogenetics had a significant impact,...