Jinfeng pills ameliorate premature ovarian insufficiency induced by cyclophosphamide in rats and correlate to modulating IL-17A/IL-6 axis and MEK/ERK signals

• Published in: Journal of ethnopharmacology Vol. 307; p. 116242
• Main Authors: Hu, Ying-yi, Zhong, Rui-hua, Guo, Xiang-jie, Li, Guo-ting, Zhou, Jie-yun, Yang, Wen-jie, Ren, Bing-tao, Zhu, Yan
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 10.05.2023
• Subjects: Animals; Cyclooxygenase 2; Cyclophosphamide; Extracellular Signal-Regulated MAP Kinases; Female; Follicle Stimulating Hormone; Humans; IL-17/IL-6; Interleukin-17; Interleukin-6; Jinfeng pill; Matrix Metalloproteinase 3; MEK/ ERK; Menopause, Premature; Mitogen-Activated Protein Kinase Kinases; Phosphatidylinositol 3-Kinases - metabolism; Premature ovarian insufficiency; Primary Ovarian Insufficiency - chemically induced; Rats; Transcriptomics; IL-17/IL-6; Jinfeng pill; MEK/ ERK; Premature ovarian insufficiency; Transcriptomics

Jinfeng Pill (JFP) is a classical Chinese medicine formula and composed of 9 herbs, including Epimedium brevicornu Maxim (Yinyanghuo), Cervus elaphus Linnaeus (Lurong), Panax ginseng C.A.Mey. (Renshen), Equus asinus (EJiao), Ligustrum lucidum W.T.Aiton (Nvzhenzi), Reynoutria multiflora (Thunb.) Mold...