Detection of metabolic syndrome with ATR-FTIR spectroscopy and chemometrics in blood plasma

• Published in: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Vol. 288; p. 122135
• Main Authors: Mateus Pereira de Souza, Nikolas, Hunter Machado, Brenda, Koche, Andreia, Beatriz Fernandes da Silva Furtado, Lucia, Becker, Débora, Antonio Corbellini, Valeriano, Rieger, Alexandre
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 05.03.2023
• Subjects: Ataxia Telangiectasia Mutated Proteins; ATR-FTIR spectroscopy; Blood plasma; Cell-Free Nucleic Acids; Chemometrics; Humans; Leptin; Metabolic syndrome; Metabolic Syndrome - diagnosis; Orthogonal partial least squares discriminant analysis; Plasma; Spectroscopy, Fourier Transform Infrared - methods; ATR-FTIR spectroscopy; Orthogonal partial least squares discriminant analysis; Metabolic syndrome; Chemometrics; Blood plasma

[Display omitted] •Pioneering study to differentiate metabolic syndrome by ATR-FTIR in blood plasma.•p < 0.05 for control vs MetS (cm−1): 1717–1703, 1166–1137, 1113–1040, and 1027–1008.•100% accuracy with OPLS-DA model to discriminate patients with metabolic syndrome.•Amide I and amide II had the...