TDP-43 and FUS–structural insights into RNA recognition and self-association

• Published in: Current opinion in structural biology Vol. 59; pp. 134 - 142
• Main Authors: Loughlin, Fionna E, Wilce, Jacqueline A
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2019

•Common and unique features influence RNA interaction and self-association by TDP-43 and FUS.•TDP-43 binds RNA sequence specifically whereas FUS binds both sequence and shape with limited specificity.•Prion-like domains of TDP-43 and FUS form reversible and irreversible aggregates.•Native oligomeriz...