Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine
•Isoliquiritigenin is a hepato-protective component in Glycyrrhizae radix.•Isoliquiritigenin improved hepatic antioxidant and anti-inflammatory capacities in vivo.•Isoliquiritigenin protected the liver against CCl4 or CCl4 plus buthionine sulfoximine.•Isoliquiritigenin inhibited CCl4-induced decreas...
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| Published in | Chemico-biological interactions Vol. 225; pp. 13 - 20 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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05.01.2015
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| Abstract | •Isoliquiritigenin is a hepato-protective component in Glycyrrhizae radix.•Isoliquiritigenin improved hepatic antioxidant and anti-inflammatory capacities in vivo.•Isoliquiritigenin protected the liver against CCl4 or CCl4 plus buthionine sulfoximine.•Isoliquiritigenin inhibited CCl4-induced decrease in cytochrome P450 2E1 in the liver.•In conclusion, isoliquiritigenin blocked the production of reactive oxygen/nitrogen species in the liver.
Glycyrrhizae radix (G. radix) has been demonstrated to have hepatoprotective properties. This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury induced by CCl4 in rats. CCl4 (0.5ml/kg/d, twice) or CCl4 plus buthionine sulfoximine exerted severe liver damage assessed by increased plasma levels of alanine aminotransferase and aspartate aminotransferase, in addition to hepatic degeneration and necrosis. These pathological changes were markedly protected by pretreatment with isoLQ (5, 20mg/kg/d, p.o.) for 3 consecutive days. In addition, pretreatment with isoLQ inhibited CCl4-induced reduction of cytochrome P450 2E1 protein and mRNA expression as well as activity in the liver. Moreover, isoLQ pretreatment reversed the decrease in hepatic antioxidant capacity induced by CCl4 as well as suppressed expression of tumor necrosis factor-alpha and cyclooxigenase-2 in the liver. These results suggest that isoLQ has a protective effect against CCl4-induced liver damage through induction of antioxidant and anti-inflammatory activities. |
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| AbstractList | Glycyrrhizae radix (G. radix) has been demonstrated to have hepatoprotective properties. This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury induced by CCl4 in rats. CCl4 (0.5 ml/kg/d, twice) or CCl4 plus buthionine sulfoximine exerted severe liver damage assessed by increased plasma levels of alanine aminotransferase and aspartate aminotransferase, in addition to hepatic degeneration and necrosis. These pathological changes were markedly protected by pretreatment with isoLQ (5, 20 mg/kg/d, p.o.) for 3 consecutive days. In addition, pretreatment with isoLQ inhibited CCl4-induced reduction of cytochrome P450 2E1 protein and mRNA expression as well as activity in the liver. Moreover, isoLQ pretreatment reversed the decrease in hepatic antioxidant capacity induced by CCl4 as well as suppressed expression of tumor necrosis factor-alpha and cyclooxigenase-2 in the liver. These results suggest that isoLQ has a protective effect against CCl4-induced liver damage through induction of antioxidant and anti-inflammatory activities. •Isoliquiritigenin is a hepato-protective component in Glycyrrhizae radix.•Isoliquiritigenin improved hepatic antioxidant and anti-inflammatory capacities in vivo.•Isoliquiritigenin protected the liver against CCl4 or CCl4 plus buthionine sulfoximine.•Isoliquiritigenin inhibited CCl4-induced decrease in cytochrome P450 2E1 in the liver.•In conclusion, isoliquiritigenin blocked the production of reactive oxygen/nitrogen species in the liver. Glycyrrhizae radix (G. radix) has been demonstrated to have hepatoprotective properties. This study determined the therapeutic effects of isoliquiritigenin (isoLQ) in G. radix, against liver injury induced by CCl4 in rats. CCl4 (0.5ml/kg/d, twice) or CCl4 plus buthionine sulfoximine exerted severe liver damage assessed by increased plasma levels of alanine aminotransferase and aspartate aminotransferase, in addition to hepatic degeneration and necrosis. These pathological changes were markedly protected by pretreatment with isoLQ (5, 20mg/kg/d, p.o.) for 3 consecutive days. In addition, pretreatment with isoLQ inhibited CCl4-induced reduction of cytochrome P450 2E1 protein and mRNA expression as well as activity in the liver. Moreover, isoLQ pretreatment reversed the decrease in hepatic antioxidant capacity induced by CCl4 as well as suppressed expression of tumor necrosis factor-alpha and cyclooxigenase-2 in the liver. These results suggest that isoLQ has a protective effect against CCl4-induced liver damage through induction of antioxidant and anti-inflammatory activities. |
| Author | Zhao, ZhengLin Kim, Young Woo Lee, Jong Rok Kim, Sang Chan Zhao, RongJie Park, Sang Mi Guan, LiXin Wu, YiYan |
| Author_xml | – sequence: 1 givenname: ZhengLin surname: Zhao fullname: Zhao, ZhengLin organization: College of Oriental Medicine, Daegu Haany University, Daegu 706-828, Republic of Korea – sequence: 2 givenname: Sang Mi surname: Park fullname: Park, Sang Mi organization: College of Oriental Medicine, Daegu Haany University, Daegu 706-828, Republic of Korea – sequence: 3 givenname: LiXin surname: Guan fullname: Guan, LiXin organization: Department of Pharmacology, Mudanjiang Medical University, Heilongjiang 157011, China – sequence: 4 givenname: YiYan surname: Wu fullname: Wu, YiYan organization: Department of Pharmacology, Mudanjiang Medical University, Heilongjiang 157011, China – sequence: 5 givenname: Jong Rok surname: Lee fullname: Lee, Jong Rok organization: College of Oriental Medicine, Daegu Haany University, Daegu 706-828, Republic of Korea – sequence: 6 givenname: Sang Chan surname: Kim fullname: Kim, Sang Chan email: sckim@dhu.ac.kr organization: College of Oriental Medicine, Daegu Haany University, Daegu 706-828, Republic of Korea – sequence: 7 givenname: Young Woo surname: Kim fullname: Kim, Young Woo email: ywkim@dhu.ac.kr organization: College of Oriental Medicine, Daegu Haany University, Daegu 706-828, Republic of Korea – sequence: 8 givenname: RongJie surname: Zhao fullname: Zhao, RongJie email: zhao_rongjie@yahoo.com organization: College of Oriental Medicine, Daegu Haany University, Daegu 706-828, Republic of Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25450236$$D View this record in MEDLINE/PubMed |
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| Keywords | Isoliquiritigenin Oxidative stress AST COX-2 Liver Carbon tetrachloride ALT SOD G. radix MDA isoLQ CAT Cytochrome P450 2E1 CYP2E1 GSH BSO |
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| Snippet | •Isoliquiritigenin is a hepato-protective component in Glycyrrhizae radix.•Isoliquiritigenin improved hepatic antioxidant and anti-inflammatory capacities in... Glycyrrhizae radix (G. radix) has been demonstrated to have hepatoprotective properties. This study determined the therapeutic effects of isoliquiritigenin... |
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| SubjectTerms | Alanine Transaminase - blood Alanine Transaminase - genetics Animals Aspartate Aminotransferases - blood Aspartate Aminotransferases - genetics Buthionine Sulfoximine - metabolism Buthionine Sulfoximine - toxicity Carbon tetrachloride Carbon Tetrachloride - metabolism Carbon Tetrachloride - toxicity Chalcones - pharmacology Chalcones - therapeutic use Chemical and Drug Induced Liver Injury - enzymology Chemical and Drug Induced Liver Injury - metabolism Cytochrome P-450 CYP2E1 - metabolism Cytochrome P450 2E1 Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Histocytochemistry Isoliquiritigenin Liver Male Oxidative stress Random Allocation Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - chemistry RNA, Messenger - genetics |
| Title | Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine |
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