Single nucleotide polymorphism of PIK3CA and its interaction with the environment are risk factors for Chinese Han ovarian cancer

• Published in: Pathology, research and practice Vol. 215; no. 9; p. 152520
• Main Authors: Zhang, Hui, Zhou, Li
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.09.2019
• Subjects: Adult; Aged; Aged, 80 and over; Alcohol Drinking - adverse effects; Asian Continental Ancestry Group; Class I Phosphatidylinositol 3-Kinases - genetics; Female; Gene-Environment Interaction; Humans; Middle Aged; Obesity - complications; Ovarian cancer; Ovarian Neoplasms - genetics; Parity; PIK3CA; Polymorphism, Single Nucleotide; Risk Factors; Single nucleotide polymorphism; Smoking - adverse effects; Single nucleotide polymorphism; PIK3CA; Gene-environment interaction; Ovarian cancer

The PI3K pathway is an important signaling network that regulates key cell functions such as cell growth, proliferation and survival. PIK3CA mutations are found in a variety of human cancers. This study aimed to analyze the effect of interactions between PIK3CA rs2699887, rs3976507, rs6443626 single...